ID   IRC22_PICGU             Reviewed;         238 AA.
AC   A5DEU9;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 40.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; ORFNames=PGUG_01800;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; CH408156; EDK37702.1; -; Genomic_DNA.
DR   RefSeq; XP_001486129.1; XM_001486079.1.
DR   AlphaFoldDB; A5DEU9; -.
DR   STRING; 4929.XP_001486129.1; -.
DR   EnsemblFungi; EDK37702; EDK37702; PGUG_01800.
DR   GeneID; 5127803; -.
DR   KEGG; pgu:PGUG_01800; -.
DR   VEuPathDB; FungiDB:PGUG_01800; -.
DR   eggNOG; ENOG502S7BF; Eukaryota.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   InParanoid; A5DEU9; -.
DR   OMA; YQEEWIP; -.
DR   OrthoDB; 1349929at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..238
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399082"
FT   TOPO_DOM        22..169
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..238
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   238 AA;  25766 MW;  8421E48A94199380 CRC64;
     MKFSLPYVAT FLGAFVAGAF AADPEASKDT TSQTVTLQFA VDYSIPHLPN VGPRDLAEVY
     NGEEFTIAYS FTNNEDKDIS IVGVGGAFHD VKTGAIKSNL TASPIEAVTV TPGESGSFSH
     KVSLNLVPEE YILVPQLFIA FDNDLKLVQA RGQRTEVKDV PISVFDPQLL LLEAILLATF
     AGLGYVAYNI WGKRYFEGTA LVNKPKRGAS PPVATAKSVD SDWLPEGHLR QKKTKKAN