ID   IRC22_PICST             Reviewed;         234 AA.
AC   A3LU17;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-APR-2007, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; ORFNames=PICST_83260;
OS   Scheffersomyces stipitis (strain ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL
OS   Y-11545) (Yeast) (Pichia stipitis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Scheffersomyces.
OX   NCBI_TaxID=322104;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58785 / CBS 6054 / NBRC 10063 / NRRL Y-11545;
RX   PubMed=17334359; DOI=10.1038/nbt1290;
RA   Jeffries T.W., Grigoriev I.V., Grimwood J., Laplaza J.M., Aerts A.,
RA   Salamov A., Schmutz J., Lindquist E., Dehal P., Shapiro H., Jin Y.-S.,
RA   Passoth V., Richardson P.M.;
RT   "Genome sequence of the lignocellulose-bioconverting and xylose-fermenting
RT   yeast Pichia stipitis.";
RL   Nat. Biotechnol. 25:319-326(2007).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; CP000498; ABN66166.1; -; Genomic_DNA.
DR   RefSeq; XP_001384195.1; XM_001384158.1.
DR   AlphaFoldDB; A3LU17; -.
DR   STRING; 4924.XP_001384195.1; -.
DR   EnsemblFungi; ABN66166; ABN66166; PICST_83260.
DR   GeneID; 4838605; -.
DR   KEGG; pic:PICST_83260; -.
DR   eggNOG; ENOG502S7BF; Eukaryota.
DR   HOGENOM; CLU_078554_0_0_1; -.
DR   InParanoid; A3LU17; -.
DR   OMA; YQEEWIP; -.
DR   OrthoDB; 1349929at2759; -.
DR   Proteomes; UP000002258; Chromosome 4.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..234
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399084"
FT   TOPO_DOM        20..162
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..234
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   234 AA;  25510 MW;  90C6F99EEF7FC88C CRC64;
     MKFSAILSAV FASIAAVSAI EPAEGRQHEI AFIVDYKIKQ QPELTQADVA EWTNGETITL
     QYHAQNNEAE EVTIIGVSGT FIEPSTGNVK VNMTAATIGP IVVAPGESHV FEQNIPLNVL
     PDHYLLVPQV YVAHEEKVKH VAIRGQLATV VEPNVSIFNP QLLFLELVLL ATFAGFGYFV
     YEFWGKQYFK GTAPVAAKVK RAASPSSATA SGKAYDESWI PEAHLKQKKT KKAA