ID   IRC22_VANPO             Reviewed;         228 AA.
AC   A7TP26;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; ORFNames=Kpol_499p23;
OS   Vanderwaltozyma polyspora (strain ATCC 22028 / DSM 70294 / BCRC 21397 / CBS
OS   2163 / NBRC 10782 / NRRL Y-8283 / UCD 57-17) (Kluyveromyces polysporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Vanderwaltozyma.
OX   NCBI_TaxID=436907;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 22028 / DSM 70294 / BCRC 21397 / CBS 2163 / NBRC 10782 / NRRL
RC   Y-8283 / UCD 57-17;
RX   PubMed=17494770; DOI=10.1073/pnas.0608218104;
RA   Scannell D.R., Frank A.C., Conant G.C., Byrne K.P., Woolfit M., Wolfe K.H.;
RT   "Independent sorting-out of thousands of duplicated gene pairs in two yeast
RT   species descended from a whole-genome duplication.";
RL   Proc. Natl. Acad. Sci. U.S.A. 104:8397-8402(2007).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; DS480437; EDO15995.1; -; Genomic_DNA.
DR   RefSeq; XP_001643853.1; XM_001643803.1.
DR   AlphaFoldDB; A7TP26; -.
DR   STRING; 436907.A7TP26; -.
DR   EnsemblFungi; EDO15995; EDO15995; Kpol_499p23.
DR   GeneID; 5544094; -.
DR   KEGG; vpo:Kpol_499p23; -.
DR   eggNOG; ENOG502S3VP; Eukaryota.
DR   HOGENOM; CLU_078554_1_0_1; -.
DR   InParanoid; A7TP26; -.
DR   OMA; YQEEWIP; -.
DR   OrthoDB; 1349929at2759; -.
DR   PhylomeDB; A7TP26; -.
DR   Proteomes; UP000000267; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..228
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399085"
FT   TOPO_DOM        18..179
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        180..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        201..228
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   228 AA;  25744 MW;  856F0CDDF0B095FE CRC64;
     MKLLFFIWFA IFSKVFGISE EVAEAADVVS EDLKEDFDVE ESPVQQYVNL NVTYSIVERP
     GLNLTDLFEF VPEETLTLNY NLYNGENSSV SVVGVSGNVY TFPDGYYAAN ITESSIEPLE
     VMFNRSAIFQ QEVRLVLPEG RYYLEPVLIV EKDEKLMRVA VQPVTVEIAP LPLSIFNPQF
     LSIIVTLGAL VGGAFYYLVY LKASTKETKG KSKTVKVDET WLPDTYKK