ID   IRC22_YEAS6             Reviewed;         225 AA.
AC   B5VHD1;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   03-AUG-2022, entry version 26.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; ORFNames=AWRI1631_50660;
OS   Saccharomyces cerevisiae (strain AWRI1631) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=545124;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AWRI1631;
RX   PubMed=18778279; DOI=10.1111/j.1567-1364.2008.00434.x;
RA   Borneman A.R., Forgan A.H., Pretorius I.S., Chambers P.J.;
RT   "Comparative genome analysis of a Saccharomyces cerevisiae wine strain.";
RL   FEMS Yeast Res. 8:1185-1195(2008).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; ABSV01000646; EDZ72661.1; -; Genomic_DNA.
DR   AlphaFoldDB; B5VHD1; -.
DR   PRIDE; B5VHD1; -.
DR   Proteomes; UP000008988; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..225
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399088"
FT   TOPO_DOM        25..169
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          203..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..225
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   225 AA;  25052 MW;  2965F5896E44A48F CRC64;
     MRFFMLIGFN LLTALSSFCA AISANNSDNV EHEQEVAEAV APPSINIEVK YDVVGKESEN
     HDSFLEFYAE DTATLAYNVT NWEDTNITIF GVNGTIVTYP HGYPVADITG ASIGPYEMEV
     NGTSKFGQDV TLNLPEGQYF LIPFLLASRF DEIVRIAAPP TLFEIVSPPI SFFNPQFLSV
     QVIFLAIIGG VSYYYMKSKT NQRPSKKSAT VKKVDESWLP ETYKK