ID   IRC22_YEAS8             Reviewed;         225 AA.
AC   C8Z6Z8;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=Increased recombination centers protein 22;
DE   Flags: Precursor;
GN   Name=IRC22; ORFNames=EC1118_1E8_0925g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC       integrity.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type I membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
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DR   EMBL; FN393067; CAY79164.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8Z6Z8; -.
DR   EnsemblFungi; CAY79164; CAY79164; EC1118_1E8_0925g.
DR   HOGENOM; CLU_078554_1_0_1; -.
DR   Proteomes; UP000000286; Chromosome V, Scaffold EC1118_1E8.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Endoplasmic reticulum; Membrane; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..225
FT                   /note="Increased recombination centers protein 22"
FT                   /id="PRO_0000399090"
FT   TOPO_DOM        22..169
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        191..225
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          203..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..225
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   225 AA;  24992 MW;  94C23FF5C98B8C39 CRC64;
     MRFSMLIGFN LLTALSSFCA AISANNSDNV EHEQEVAEAV APPSINIEVK YDVVGKESEN
     HDSFLEFYAE DTATLAYNVT NWEDTNITIF GVNGTIVTYP HGYPVADITG ASIGPYEMEV
     NGTSKFGQDV TLNLPEGQYF LIPFLLASRF DEIVRIAAPP TLFEIVSPPI SFFNPQFLSV
     QVIFLAIIGG VSYYYMKSKT NQRPSKKSAT VKKVDESWLP ETYKK