IRC22_ZYGRC
ID IRC22_ZYGRC Reviewed; 227 AA.
AC C5DVU3;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 2.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=Increased recombination centers protein 22;
DE Flags: Precursor;
GN Name=IRC22; OrderedLocusNames=ZYRO0D09438g;
OS Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS / NRRL Y-229) (Candida mogii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX NCBI_TaxID=559307;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC Y-229;
RX PubMed=19525356; DOI=10.1101/gr.091546.109;
RG The Genolevures Consortium;
RA Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT "Comparative genomics of protoploid Saccharomycetaceae.";
RL Genome Res. 19:1696-1709(2009).
CC -!- FUNCTION: Is probably involved in a pathway contributing to genomic
CC integrity.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC Single-pass type I membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRC22 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAR27912.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; CU928176; CAR27912.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_002496845.1; XM_002496800.1.
DR AlphaFoldDB; C5DVU3; -.
DR STRING; 559307.C5DVU3; -.
DR EnsemblFungi; CAR27912; CAR27912; ZYRO0D09438g.
DR GeneID; 8204102; -.
DR KEGG; zro:ZYRO0D09438g; -.
DR HOGENOM; CLU_078554_1_0_1; -.
DR InParanoid; C5DVU3; -.
DR Proteomes; UP000008536; Chromosome D.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Membrane; Reference proteome; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..227
FT /note="Increased recombination centers protein 22"
FT /id="PRO_0000399091"
FT TOPO_DOM 22..172
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 173..193
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 194..227
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 199..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 24756 MW; F3FF10C38C70A688 CRC64;
MKLFQLTLFL LVNAFLALAS SESVDVESSS NETAVEEPST IDFDVGYNIL EHLDTDLSRG
VEFSMQEVAT FNYSFTNNEK VNVSVVGVAG SVISTPDGYQ VANITEQPIG PVPIGVNETA
NFQAGVQLIL PEGNFYMLPV LNVMKDGEPL RVGIRPLLIT VNPPPLSFFN PSFLSVQILL
GLLIAGATYA FITFDKSETK RKPAKNAKPV AVDQSWLPDT YKKPEKP
