IRC3_SCHPO
ID IRC3_SCHPO Reviewed; 606 AA.
AC Q1MTR1;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Putative mitochondrial ATP-dependent helicase irc3;
DE EC=3.6.4.-;
GN Name=irc3; ORFNames=SPBC11C11.11c, SPBC3B8.12;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the helicase family. IRC3 subfamily.
CC {ECO:0000305}.
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DR EMBL; CU329671; CAA20693.2; -; Genomic_DNA.
DR RefSeq; XP_001713145.1; XM_001713093.1.
DR AlphaFoldDB; Q1MTR1; -.
DR SMR; Q1MTR1; -.
DR BioGRID; 276171; 10.
DR STRING; 4896.SPBC11C11.11c.1; -.
DR REBASE; 190417; Bce021ORF874P.
DR MaxQB; Q1MTR1; -.
DR PaxDb; Q1MTR1; -.
DR PRIDE; Q1MTR1; -.
DR EnsemblFungi; SPBC11C11.11c.1; SPBC11C11.11c.1:pep; SPBC11C11.11c.
DR PomBase; SPBC11C11.11c; irc3.
DR VEuPathDB; FungiDB:SPBC11C11.11c; -.
DR eggNOG; ENOG502QT4U; Eukaryota.
DR HOGENOM; CLU_014765_0_0_1; -.
DR InParanoid; Q1MTR1; -.
DR OMA; DCHIIDM; -.
DR PhylomeDB; Q1MTR1; -.
DR PRO; PR:Q1MTR1; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005737; C:cytoplasm; HDA:PomBase.
DR GO; GO:0005759; C:mitochondrial matrix; ISO:PomBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003724; F:RNA helicase activity; IBA:GO_Central.
DR GO; GO:0032042; P:mitochondrial DNA metabolic process; ISO:PomBase.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding; Helicase; Hydrolase; Mitochondrion; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..606
FT /note="Putative mitochondrial ATP-dependent helicase irc3"
FT /id="PRO_0000353817"
FT DOMAIN 40..201
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
FT DOMAIN 246..398
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00542"
FT MOTIF 148..151
FT /note="DEAH box"
FT BINDING 53..60
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00541"
SQ SEQUENCE 606 AA; 68943 MW; 97F729852B824547 CRC64;
MLLNACCKKN LWPRNGSTIF RRFALKLRPY QEECLSACLN AFDEGKRRIA VSLATGSGKT
ALFPHFIKYA PTLRPNSEQC LILVHRKELA LQALKHCRES LPNKSIEIDM GNQCASGLAD
VTVASVFSLK NERLLKYNPL NFKLLIFDEV HHMASPSYLR ILEHFGAESE KSKVNVIGLT
ATLFRADGKG LACGLDEIVY HRHFVDMIKD NWLVEPKVIN IKWSTDLVLA DSSSFLDQEK
LKKEAQSEKA IFEIPRAWLE HASNRSSTLV FCINVEHSLK VCNAFRKLGI DARALFGETN
DSERETLIQD FRKKKFPVLV NCMVLTEGTD IPNIDCLMIA RPTSSPNLLT QMIGRGLRLH
EGKRDCLILD FCDSLRRVSL HVDPTLAGLS PDEVENFYNK SKNSLANPDY DPKIYGLQSV
LWYSKLRKLI EMMDNIKNKD RSIFNLSTNA WVAVGMGRYV LSFLQKVLII DTNFEDGTHK
ISEYTKEKLG TRVYNRKRIV SDRIPSLKFA IRAAETYISN LKTPRSLISR KAVWRMRPAS
VRQINFLKKS NLKLDEKLLT AGVAADMITK VIYGGKGRQV RTDKLQSYLK HDANLKRITT
LKELKG
