IRC4_YEAST
ID IRC4_YEAST Reviewed; 179 AA.
AC Q03036; D6VTF9;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Uncharacterized protein IRC4;
DE AltName: Full=Increased recombination centers protein 4;
GN Name=IRC4; OrderedLocusNames=YDR540C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 172 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; U43834; AAB64982.1; -; Genomic_DNA.
DR EMBL; AY692651; AAT92670.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA12369.1; -; Genomic_DNA.
DR PIR; S62019; S62019.
DR RefSeq; NP_010829.1; NM_001180848.1.
DR PDB; 5COG; X-ray; 1.61 A; A/B=1-179.
DR PDBsum; 5COG; -.
DR AlphaFoldDB; Q03036; -.
DR SMR; Q03036; -.
DR BioGRID; 32587; 79.
DR IntAct; Q03036; 1.
DR STRING; 4932.YDR540C; -.
DR MaxQB; Q03036; -.
DR PaxDb; Q03036; -.
DR PRIDE; Q03036; -.
DR EnsemblFungi; YDR540C_mRNA; YDR540C; YDR540C.
DR GeneID; 852153; -.
DR KEGG; sce:YDR540C; -.
DR SGD; S000002948; IRC4.
DR VEuPathDB; FungiDB:YDR540C; -.
DR eggNOG; ENOG502SPSX; Eukaryota.
DR HOGENOM; CLU_124046_0_0_1; -.
DR InParanoid; Q03036; -.
DR OMA; KWTLGRM; -.
DR BioCyc; YEAST:G3O-30048-MON; -.
DR PRO; PR:Q03036; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; Q03036; protein.
DR GO; GO:0005737; C:cytoplasm; HDA:SGD.
DR GO; GO:0005634; C:nucleus; HDA:SGD.
DR GO; GO:0006312; P:mitotic recombination; IMP:SGD.
DR GO; GO:1990414; P:replication-born double-strand break repair via sister chromatid exchange; IMP:SGD.
DR Gene3D; 1.20.120.450; -; 1.
DR InterPro; IPR034660; DinB/YfiT-like.
DR InterPro; IPR012550; DUF1706.
DR PANTHER; PTHR40658; PTHR40658; 1.
DR Pfam; PF08020; DUF1706; 1.
DR PIRSF; PIRSF031551; DUF1706; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..179
FT /note="Uncharacterized protein IRC4"
FT /id="PRO_0000253886"
FT HELIX 7..23
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 24..27
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 30..32
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 44..66
FT /evidence="ECO:0007829|PDB:5COG"
FT STRAND 73..75
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 80..82
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 83..94
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 99..119
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 122..126
FT /evidence="ECO:0007829|PDB:5COG"
FT STRAND 127..130
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 133..136
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 142..149
FT /evidence="ECO:0007829|PDB:5COG"
FT HELIX 151..167
FT /evidence="ECO:0007829|PDB:5COG"
SQ SEQUENCE 179 AA; 21519 MW; 5CFD33692806EF93 CRC64;
MREYTSKKEL KEEIEKKYEK YDAEFETISE SQKDEKVETV DRTPSENLSY QLGWVNLLLE
WEAKEIAGYN VETPAPGYKW NNLGGLYQSF YKKYGIYSIK EQRAKLREAV NEVYKWISTL
SDDELFQAGN RKWATTKAMW PVYKWIHINT VAPFTNFRGK IRKWKRLVPE EQRIKRRKI
