ID   IRC6_ASHGO              Reviewed;         304 AA.
AC   Q753S8;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Increased recombination centers protein 6;
GN   Name=IRC6; OrderedLocusNames=AFR248C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in gross chromosomal rearrangements (GCRs) and
CC       telomere healing. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC6 family. {ECO:0000305}.
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DR   EMBL; AE016819; AAS53619.1; -; Genomic_DNA.
DR   RefSeq; NP_985795.1; NM_211150.1.
DR   AlphaFoldDB; Q753S8; -.
DR   SMR; Q753S8; -.
DR   STRING; 33169.AAS53619; -.
DR   EnsemblFungi; AAS53619; AAS53619; AGOS_AFR248C.
DR   GeneID; 4622058; -.
DR   KEGG; ago:AGOS_AFR248C; -.
DR   eggNOG; ENOG502S7AE; Eukaryota.
DR   HOGENOM; CLU_079666_0_0_1; -.
DR   InParanoid; Q753S8; -.
DR   OMA; GLMFTIN; -.
DR   Proteomes; UP000000591; Chromosome VI.
DR   GO; GO:0030674; F:protein-macromolecule adaptor activity; IBA:GO_Central.
DR   GO; GO:0016192; P:vesicle-mediated transport; IBA:GO_Central.
DR   InterPro; IPR034627; Irc6.
DR   PANTHER; PTHR28043; PTHR28043; 1.
PE   3: Inferred from homology;
KW   Chromosomal rearrangement; Reference proteome.
FT   CHAIN           1..304
FT                   /note="Increased recombination centers protein 6"
FT                   /id="PRO_0000399215"
SQ   SEQUENCE   304 AA;  34157 MW;  DABF124A71D0F8BB CRC64;
     MVAEGLCQCY IRRMSTGGPH GAAPDRSCLA RDTEGRSPCK NCQGCTQGAA DPIPIRILMA
     DSDVEQAPSV SVLPRNKILI LAPAGKAYQA EVIRDLFNIE ASESDRIVRD VKWSNKYYEV
     DLDLYIDSYE SLQTWGAEFC SDECADLRDV VAGIFLVFEE TEDAETFQQL IEDCHFTDER
     VLVACDLSSA EHPASLERAL EVHDVALVRW RERGTNELGE QQGRERVREL LDIHPWSERM
     LRMHASTAAA LAELDPLQAD IPLDSVVTRI KQARERYLEI TDVHAADEYA ARIAHELTEQ
     LLPE