ID   IRC6_KLULA              Reviewed;         233 AA.
AC   Q6CYE2;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Increased recombination centers protein 6;
GN   Name=IRC6; OrderedLocusNames=KLLA0A01089g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in gross chromosomal rearrangements (GCRs) and
CC       telomere healing. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRC6 family. {ECO:0000305}.
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DR   EMBL; CR382121; CAH02635.1; -; Genomic_DNA.
DR   RefSeq; XP_451047.1; XM_451047.1.
DR   AlphaFoldDB; Q6CYE2; -.
DR   SMR; Q6CYE2; -.
DR   STRING; 28985.XP_451047.1; -.
DR   EnsemblFungi; CAH02635; CAH02635; KLLA0_A01089g.
DR   GeneID; 2896605; -.
DR   KEGG; kla:KLLA0_A01089g; -.
DR   eggNOG; ENOG502S7AE; Eukaryota.
DR   HOGENOM; CLU_079666_0_0_1; -.
DR   InParanoid; Q6CYE2; -.
DR   OMA; GLMFTIN; -.
DR   Proteomes; UP000000598; Chromosome A.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR034627; Irc6.
DR   PANTHER; PTHR28043; PTHR28043; 1.
PE   3: Inferred from homology;
KW   Chromosomal rearrangement; Reference proteome.
FT   CHAIN           1..233
FT                   /note="Increased recombination centers protein 6"
FT                   /id="PRO_0000399222"
SQ   SEQUENCE   233 AA;  27635 MW;  EFED68182FBEAD57 CRC64;
     MDNHKVLILL PESLEIQEHI AFISTIFQKQ YDETESIARD VQWKTKYYET TLDLYIDTYD
     VLQEWVNDFV SDECKELRDV ISGIIFVFKD EDHKPPVECL KNLIDERIED FTAKFFIGCY
     FNENVIEEDE LYELNSDLLV QNFEIVNWFD KPDPSMDKVG SERIKEIIDV HPWLSHPETL
     KKNQGQINIS PIDLDSFMTK LEQAKERYQT FDDSKEAELF IEKIIDELSD MIV