IRC6_YEAST
ID IRC6_YEAST Reviewed; 237 AA.
AC P43615; D6VTS6;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Increased recombination centers protein 6;
GN Name=IRC6; OrderedLocusNames=YFR043C;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204511 / S288c / AB972;
RX PubMed=8686379;
RX DOI=10.1002/(sici)1097-0061(199602)12:2<149::aid-yea893>3.0.co;2-g;
RA Eki T., Naitou M., Hagiwara H., Ozawa M., Sasanuma S., Sasanuma M.,
RA Tsuchiya Y., Shibata T., Hanaoka F., Murakami Y.;
RT "Analysis of a 36.2 kb DNA sequence including the right telomere of
RT chromosome VI from Saccharomyces cerevisiae.";
RL Yeast 12:149-167(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7670463; DOI=10.1038/ng0795-261;
RA Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S.,
RA Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H.,
RA Eki T.;
RT "Analysis of the nucleotide sequence of chromosome VI from Saccharomyces
RT cerevisiae.";
RL Nat. Genet. 10:261-268(1995).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP DISRUPTION PHENOTYPE.
RX PubMed=18085829; DOI=10.1371/journal.pgen.0030228;
RA Alvaro D., Lisby M., Rothstein R.;
RT "Genome-wide analysis of Rad52 foci reveals diverse mechanisms impacting
RT recombination.";
RL PLoS Genet. 3:E228-E228(2007).
RN [5]
RP FUNCTION.
RX PubMed=20194442; DOI=10.1101/gad.1869110;
RA Zhang W., Durocher D.;
RT "De novo telomere formation is suppressed by the Mec1-dependent inhibition
RT of Cdc13 accumulation at DNA breaks.";
RL Genes Dev. 24:502-515(2010).
CC -!- FUNCTION: Involved in gross chromosomal rearrangements (GCRs) and
CC telomere healing. {ECO:0000269|PubMed:20194442}.
CC -!- DISRUPTION PHENOTYPE: Displays increased levels of spontaneous RAD52
CC foci in proliferating diploid cells. {ECO:0000269|PubMed:18085829}.
CC -!- SIMILARITY: Belongs to the IRC6 family. {ECO:0000305}.
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DR EMBL; D50617; BAA09282.1; -; Genomic_DNA.
DR EMBL; BK006940; DAA12486.1; -; Genomic_DNA.
DR PIR; S56298; S56298.
DR RefSeq; NP_116701.3; NM_001180008.3.
DR PDB; 3UC9; X-ray; 1.80 A; A=1-213.
DR PDBsum; 3UC9; -.
DR AlphaFoldDB; P43615; -.
DR SMR; P43615; -.
DR BioGRID; 31201; 77.
DR DIP; DIP-1851N; -.
DR IntAct; P43615; 3.
DR MINT; P43615; -.
DR STRING; 4932.YFR043C; -.
DR MaxQB; P43615; -.
DR PaxDb; P43615; -.
DR PRIDE; P43615; -.
DR EnsemblFungi; YFR043C_mRNA; YFR043C; YFR043C.
DR GeneID; 850604; -.
DR KEGG; sce:YFR043C; -.
DR SGD; S000001939; IRC6.
DR VEuPathDB; FungiDB:YFR043C; -.
DR eggNOG; ENOG502S7AE; Eukaryota.
DR HOGENOM; CLU_079666_0_0_1; -.
DR InParanoid; P43615; -.
DR OMA; GLMFTIN; -.
DR BioCyc; YEAST:G3O-30490-MON; -.
DR PRO; PR:P43615; -.
DR Proteomes; UP000002311; Chromosome VI.
DR RNAct; P43615; protein.
DR GO; GO:0030674; F:protein-macromolecule adaptor activity; IDA:SGD.
DR GO; GO:0016192; P:vesicle-mediated transport; IGI:SGD.
DR InterPro; IPR034627; Irc6.
DR PANTHER; PTHR28043; PTHR28043; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Chromosomal rearrangement; Reference proteome.
FT CHAIN 1..237
FT /note="Increased recombination centers protein 6"
FT /id="PRO_0000202696"
FT STRAND 9..15
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 16..18
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 19..30
FT /evidence="ECO:0007829|PDB:3UC9"
FT STRAND 39..46
FT /evidence="ECO:0007829|PDB:3UC9"
FT STRAND 51..62
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 64..71
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 74..76
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 77..81
FT /evidence="ECO:0007829|PDB:3UC9"
FT STRAND 83..90
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 92..95
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 97..99
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 101..107
FT /evidence="ECO:0007829|PDB:3UC9"
FT STRAND 113..118
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 125..135
FT /evidence="ECO:0007829|PDB:3UC9"
FT STRAND 138..141
FT /evidence="ECO:0007829|PDB:3UC9"
FT STRAND 143..147
FT /evidence="ECO:0007829|PDB:3UC9"
FT HELIX 165..175
FT /evidence="ECO:0007829|PDB:3UC9"
SQ SEQUENCE 237 AA; 27879 MW; D1F36471AEF1FD3C CRC64;
MVLQYPQNKI LVLSDHPHNF LKTQFLQDLF HCSSTGISIV KDQTWENRYY KVHFDLYIDS
CKEIPVWVEE FITPECEPLR NVMAGIILIT DIRQTKPQEL LHQFMIAAHR NTFVVLANVN
EEVEQDEIDE LNEIWSNAFT NVIEFVNWKR SKPTVNHNDY GEKLGLDRIQ EIIDTHDWLN
CEVQPATKIR EEIPNEMPLE QIIRNLQSAR LKYKSIENSS EADAFANEMA DELSRYL
