ID   APRIO_BOVIN             Reviewed;          81 AA.
AC   F7VJQ2;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Alternative prion protein;
DE   AltName: Full=AltPrP;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=21478263; DOI=10.1096/fj.10-173815;
RA   Vanderperre B., Staskevicius A.B., Tremblay G., McCoy M., O'Neill M.A.,
RA   Cashman N.R., Roucou X.;
RT   "An overlapping reading frame in the PRNP gene encodes a novel polypeptide
RT   distinct from the prion protein.";
RL   FASEB J. 25:2373-2386(2011).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein.
CC   -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC       also produces the major prion protein/PRNP from an overlapping reading
CC       frame.
CC   -!- MISCELLANEOUS: The alternative prion protein and PRNP (AC P10279) have
CC       no apparent direct functional relation since a mutation that removes
CC       the start codon of the AltPrP has no apparent effect on the biology of
CC       PRNP (By similarity). In mouse and hamster, the alternative initiation
CC       AUG codon is absent and is replaced by a GUG codon. {ECO:0000250}.
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DR   EMBL; AAFC03011819; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK007888; DAA34791.1; -; Genomic_DNA.
DR   RefSeq; NP_001258554.1; NM_001271625.2.
DR   AlphaFoldDB; F7VJQ2; -.
DR   BioGRID; 158758; 3.
DR   GeneID; 281427; -.
DR   KEGG; bta:281427; -.
DR   CTD; 5621; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..81
FT                   /note="Alternative prion protein"
FT                   /id="PRO_0000420426"
FT   TRANSMEM        50..66
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   81 AA;  9763 MW;  AFD55D00CF7C6057 CRC64;
     MEHWGEPIPR TGQSWRQPLS TSGRGWLGSA PWRWLGPASW RWLGPASWRW LGSAPWWWLG
     TATWWWRLGS RWYPRSMEQT Q