ID   APRIO_SHEEP             Reviewed;          64 AA.
AC   F7VJQ3;
DT   28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT   21-SEP-2011, sequence version 1.
DT   25-MAY-2022, entry version 11.
DE   RecName: Full=Alternative prion protein;
DE   AltName: Full=AltPrP;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Roucou X.;
RL   Submitted (SEP-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=21478263; DOI=10.1096/fj.10-173815;
RA   Vanderperre B., Staskevicius A.B., Tremblay G., McCoy M., O'Neill M.A.,
RA   Cashman N.R., Roucou X.;
RT   "An overlapping reading frame in the PRNP gene encodes a novel polypeptide
RT   distinct from the prion protein.";
RL   FASEB J. 25:2373-2386(2011).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
CC       Single-pass membrane protein {ECO:0000250}.
CC   -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC       also produces the major prion protein/PRNP from an overlapping reading
CC       frame.
CC   -!- MISCELLANEOUS: The alternative prion protein and PRNP (AC P23907) have
CC       no apparent direct functional relation since a mutation that removes
CC       the start codon of the AltPrP has no apparent effect on the biology of
CC       PRNP (By similarity). In mouse and hamster, the alternative initiation
CC       AUG codon is absent and is replaced by a GUG codon. {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE993880; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BK007889; DAA34792.1; -; Genomic_DNA.
DR   AlphaFoldDB; F7VJQ3; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
PE   3: Inferred from homology;
KW   Membrane; Mitochondrion; Mitochondrion outer membrane; Reference proteome;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..64
FT                   /note="Alternative prion protein"
FT                   /id="PRO_0000420425"
FT   TRANSMEM        40..58
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   64 AA;  7619 MW;  00B917A13D0DA1E4 CRC64;
     MEHWGEPIPG TGQSWRQPLS TSGRGWLGSA PWRWLGPTSW RWLGSAPWWW LGTATWWWRL
     GSRW