ID   IRF3_CHICK              Reviewed;         491 AA.
AC   Q90643;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Interferon regulatory factor 3;
DE            Short=IRF-3;
GN   Name=IRF3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND INDUCTION BY
RP   POLY I:C.
RC   TISSUE=Liver;
RX   PubMed=7541908; DOI=10.1093/nar/23.12.2137;
RA   Grant C.E., Vasa M.Z., Deeley R.G.;
RT   "cIRF-3, a new member of the interferon regulatory factor (IRF) family that
RT   is rapidly and transiently induced by dsRNA.";
RL   Nucleic Acids Res. 23:2137-2146(1995).
CC   -!- FUNCTION: Key transcriptional regulator of type I interferon (IFN)-
CC       dependent immune responses which plays a critical role in the innate
CC       immune response against DNA and RNA viruses. Regulates the
CC       transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-
CC       stimulated genes (ISG) by binding to an interferon-stimulated response
CC       element (ISRE) in their promoters. May activate transcription by
CC       complex formation with other transcriptional factors, possibly members
CC       of the STAT family. Binds specifically to the IFN-stimulated response
CC       element (ISRE) but not to the IRF-1 binding site PRD-I.
CC       {ECO:0000250|UniProtKB:Q14653, ECO:0000269|PubMed:7541908}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q14653}. Nucleus
CC       {ECO:0000250|UniProtKB:Q14653}. Note=Shuttles between cytoplasmic and
CC       nuclear compartments, with export being the prevailing effect. When
CC       activated, IRF3 interaction with CREBBP prevents its export to the
CC       cytoplasm. {ECO:0000250|UniProtKB:Q14653}.
CC   -!- TISSUE SPECIFICITY: Widely expressed with higher expression in lung,
CC       spleen and intestine. {ECO:0000269|PubMed:7541908}.
CC   -!- INDUCTION: Up-regulated by poly I:C. {ECO:0000269|PubMed:7541908}.
CC   -!- SIMILARITY: Belongs to the IRF family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00840}.
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DR   EMBL; U20338; AAA86995.1; -; mRNA.
DR   PIR; S56753; S56753.
DR   RefSeq; NP_990703.1; NM_205372.1.
DR   AlphaFoldDB; Q90643; -.
DR   SMR; Q90643; -.
DR   STRING; 9031.ENSGALP00000038233; -.
DR   PaxDb; Q90643; -.
DR   GeneID; 396330; -.
DR   KEGG; gga:396330; -.
DR   CTD; 3665; -.
DR   VEuPathDB; HostDB:geneid_396330; -.
DR   eggNOG; ENOG502R2I9; Eukaryota.
DR   InParanoid; Q90643; -.
DR   OrthoDB; 648909at2759; -.
DR   PhylomeDB; Q90643; -.
DR   Reactome; R-GGA-1227882; TRAF mediated activation of IRF.
DR   Reactome; R-GGA-433819; Viral dsRNA:TLR3:TICAM1 Complex Activates IKBKE_CHICK.
DR   Reactome; R-GGA-434136; Viral dsRNA:TLR3:TICAM1 Complex Activates TBK1.
DR   PRO; PR:Q90643; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0002376; P:immune system process; IBA:GO_Central.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProt.
DR   GO; GO:0032481; P:positive regulation of type I interferon production; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0002224; P:toll-like receptor signaling pathway; NAS:AgBase.
DR   GO; GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; ISS:UniProtKB.
DR   CDD; cd00103; IRF; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.200.10; -; 1.
DR   InterPro; IPR019817; Interferon_reg_fac_CS.
DR   InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR   InterPro; IPR019471; Interferon_reg_factor-3.
DR   InterPro; IPR017855; SMAD-like_dom_sf.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00605; IRF; 1.
DR   Pfam; PF10401; IRF-3; 1.
DR   PRINTS; PR00267; INTFRNREGFCT.
DR   SMART; SM00348; IRF; 1.
DR   SMART; SM01243; IRF-3; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   PROSITE; PS00601; IRF_1; 1.
DR   PROSITE; PS51507; IRF_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Antiviral defense; Cytoplasm; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..491
FT                   /note="Interferon regulatory factor 3"
FT                   /id="PRO_0000154555"
FT   DNA_BIND        12..116
FT                   /note="IRF tryptophan pentad repeat"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00840"
SQ   SEQUENCE   491 AA;  54442 MW;  CAE0C2AA8BE976D9 CRC64;
     MAALDSEGDA QKLRFGPWLL NAVSSGLYRG LCWIDPDRRI FRIPWKHNAR KDVTSSDVEI
     FKAWAKASGR YEGNAEDPAK WKTNFRCALR STHMFMLLED RSKCNDDPHK VYAVASGVPN
     DRGSGGPVAG ALQQQPQLLL NHHDLALENT PTDSTEGVAA AALTQVDLDL LQSVLQHCNI
     SALGSQPTLW AHTGDALPED ALLLPGQDGC LPGPQFQDWR QLEEPLLLGN QPLTGGGCGQ
     DGAGALPVSE ECAIPAPSPA EELLFQSANP APPPPAGDIG GLPPLLDITI YYRGKMVYQE
     QVDDSRCVLA YQPLDPAVAE QRLVLFPSPA SLPDPRQRRY TEDLLEVAGL RLEQRAGQLL
     ATRLKKCKVF WALSQQLEGG EPPLNLLHRD QETTIFDFRV FCTELRDFRD SRRERSPDFT
     IFLCFGQCFS STKPKESKLI LVKLVPQFCE YWYEQVQRGG ASSLNSGNVS LQLSDSFNLF
     ELIEQYHMQT D