ID   IRF6_BOVIN              Reviewed;         467 AA.
AC   Q08DD6;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Interferon regulatory factor 6;
DE            Short=IRF-6;
GN   Name=IRF6;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probable DNA-binding transcriptional activator. It is a key
CC       determinant of the keratinocyte proliferation-differentiation switch
CC       involved in appropriate epidermal development. Plays a role in
CC       regulating mammary epithelial cell proliferation (By similarity). May
CC       regulate WDR65 transcription (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with SERPINB5. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Cytoplasm {ECO:0000250}.
CC       Note=Translocates to nucleus in response to an activating signal.
CC       {ECO:0000250}.
CC   -!- PTM: Phosphorylated. Phosphorylation status depends on the cell cycle
CC       and is a signal for ubiquitination and proteasome-mediated degradation.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRF family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00840}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC123806; AAI23807.1; -; mRNA.
DR   RefSeq; NP_001070402.1; NM_001076934.1.
DR   RefSeq; XP_005217446.1; XM_005217389.3.
DR   RefSeq; XP_005217448.1; XM_005217391.3.
DR   RefSeq; XP_015330773.1; XM_015475287.1.
DR   AlphaFoldDB; Q08DD6; -.
DR   SMR; Q08DD6; -.
DR   GeneID; 614253; -.
DR   KEGG; bta:614253; -.
DR   CTD; 3664; -.
DR   HOGENOM; CLU_031544_0_1_1; -.
DR   InParanoid; Q08DD6; -.
DR   OrthoDB; 648909at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0002376; P:immune system process; IBA:GO_Central.
DR   GO; GO:0060644; P:mammary gland epithelial cell differentiation; ISS:UniProtKB.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00103; IRF; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 2.60.200.10; -; 1.
DR   InterPro; IPR019817; Interferon_reg_fac_CS.
DR   InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR   InterPro; IPR019471; Interferon_reg_factor-3.
DR   InterPro; IPR017855; SMAD-like_dom_sf.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00605; IRF; 1.
DR   Pfam; PF10401; IRF-3; 1.
DR   PRINTS; PR00267; INTFRNREGFCT.
DR   SMART; SM00348; IRF; 1.
DR   SMART; SM01243; IRF-3; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   SUPFAM; SSF49879; SSF49879; 1.
DR   PROSITE; PS00601; IRF_1; 1.
DR   PROSITE; PS51507; IRF_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Differentiation; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation; Ubl conjugation.
FT   CHAIN           1..467
FT                   /note="Interferon regulatory factor 6"
FT                   /id="PRO_0000271386"
FT   DNA_BIND        7..115
FT                   /note="IRF tryptophan pentad repeat"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00840"
FT   REGION          121..156
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   467 AA;  53105 MW;  576256716A0D8E0E CRC64;
     MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ EEENTIFKAW
     AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT KEVPMNPVKI YQVCDIPQPQ
     GSIINPGSTG SAPWDEKDND VDEEDEEDEL DQSQHHVPIQ DTFPFLNING SPIAPASVGN
     CSVGNCSPEA VWPKTEPLEM EVPQAPIQPF YSSPELWISS LPMTDLDIKF QYRGKEYGQT
     MTVSNPQGCR LFYGDLGPMP DQEELFGPVS LEQVKFPGPE HITNEKQKLF TSKLLDVMDR
     GLILEVSGHA IYAIRLCQCK VYWSGPCAPS LVAPNLIERQ KKVKLFCLET FLSDLIAHQK
     GQIEKQPPFE IYLCFGEEWP DGKPQERKLI LVQVIPVVAR MIYEMFSGDF TRSFDSGSVR
     LQISTPDIKD NIVAQLKQLY RILQTQESWQ PMQPAPSMQL PTTLPAQ