IRF8_CHICK
ID IRF8_CHICK Reviewed; 425 AA.
AC Q90871;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Interferon regulatory factor 8 {ECO:0000305};
DE Short=IRF-8;
DE AltName: Full=Interferon consensus sequence-binding protein {ECO:0000303|PubMed:7536924};
DE Short=ICSBP {ECO:0000303|PubMed:7536924};
GN Name=IRF8; Synonyms=ICSBP {ECO:0000303|PubMed:7536924}, ICSBP1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=7536924; DOI=10.1073/pnas.92.8.3105;
RA Jungwirth C., Rebbert M., Ozato K., Degen H.J., Schultz U., Dawid I.B.;
RT "Chicken interferon consensus sequence-binding protein (ICSBP) and
RT interferon regulatory factor (IRF) 1 genes reveal evolutionary conservation
RT in the IRF gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:3105-3109(1995).
CC -!- FUNCTION: Plays a role as a transcriptional activator or repressor.
CC Specifically binds to the upstream regulatory region of type I IFN and
CC IFN-inducible MHC class I genes (the interferon consensus sequence
CC (ICS)). Plays a regulatory role in cells of the immune system (By
CC similarity). {ECO:0000250|UniProtKB:P23611,
CC ECO:0000250|UniProtKB:Q02556}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q02556}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q02556}. Note=In resting macrophages, localizes
CC in the cytoplasm. Translocated in the nucleus upon IFN-gamma induction.
CC {ECO:0000250|UniProtKB:Q02556}.
CC -!- SIMILARITY: Belongs to the IRF family. {ECO:0000255|PROSITE-
CC ProRule:PRU00840}.
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DR EMBL; L39767; AAA62159.1; -; mRNA.
DR RefSeq; NP_990747.1; NM_205416.1.
DR RefSeq; XP_015148037.1; XM_015292551.1.
DR RefSeq; XP_015148038.1; XM_015292552.1.
DR RefSeq; XP_015148039.1; XM_015292553.1.
DR AlphaFoldDB; Q90871; -.
DR SMR; Q90871; -.
DR STRING; 9031.ENSGALP00000009229; -.
DR PaxDb; Q90871; -.
DR Ensembl; ENSGALT00000009243; ENSGALP00000009229; ENSGALG00000005757.
DR GeneID; 396385; -.
DR KEGG; gga:396385; -.
DR CTD; 3394; -.
DR VEuPathDB; HostDB:geneid_396385; -.
DR eggNOG; ENOG502QT9P; Eukaryota.
DR GeneTree; ENSGT00940000158140; -.
DR HOGENOM; CLU_031544_1_1_1; -.
DR InParanoid; Q90871; -.
DR OMA; EPSCVDE; -.
DR OrthoDB; 648909at2759; -.
DR PhylomeDB; Q90871; -.
DR TreeFam; TF328512; -.
DR PRO; PR:Q90871; -.
DR Proteomes; UP000000539; Chromosome 11.
DR Bgee; ENSGALG00000005757; Expressed in spleen and 13 other tissues.
DR ExpressionAtlas; Q90871; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071346; P:cellular response to interferon-gamma; ISS:UniProtKB.
DR GO; GO:0071222; P:cellular response to lipopolysaccharide; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0042832; P:defense response to protozoan; IEA:Ensembl.
DR GO; GO:0097028; P:dendritic cell differentiation; ISS:UniProtKB.
DR GO; GO:0002316; P:follicular B cell differentiation; IEA:Ensembl.
DR GO; GO:0002314; P:germinal center B cell differentiation; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; ISS:UniProtKB.
DR GO; GO:0002376; P:immune system process; IBA:GO_Central.
DR GO; GO:0030099; P:myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006909; P:phagocytosis; IEA:Ensembl.
DR GO; GO:0002273; P:plasmacytoid dendritic cell differentiation; ISS:UniProtKB.
DR GO; GO:0032729; P:positive regulation of interferon-gamma production; IEA:Ensembl.
DR GO; GO:0032735; P:positive regulation of interleukin-12 production; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0032479; P:regulation of type I interferon production; ISS:UniProtKB.
DR CDD; cd00103; IRF; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR Gene3D; 2.60.200.10; -; 1.
DR InterPro; IPR019817; Interferon_reg_fac_CS.
DR InterPro; IPR001346; Interferon_reg_fact_DNA-bd_dom.
DR InterPro; IPR019471; Interferon_reg_factor-3.
DR InterPro; IPR044400; IRF8.
DR InterPro; IPR017855; SMAD-like_dom_sf.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11949:SF7; PTHR11949:SF7; 1.
DR Pfam; PF00605; IRF; 1.
DR Pfam; PF10401; IRF-3; 1.
DR PRINTS; PR00267; INTFRNREGFCT.
DR SMART; SM00348; IRF; 1.
DR SMART; SM01243; IRF-3; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
DR SUPFAM; SSF49879; SSF49879; 1.
DR PROSITE; PS00601; IRF_1; 1.
DR PROSITE; PS51507; IRF_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..425
FT /note="Interferon regulatory factor 8"
FT /id="PRO_0000154566"
FT DNA_BIND 7..114
FT /note="IRF tryptophan pentad repeat"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00840"
SQ SEQUENCE 425 AA; 49171 MW; 92BB8A9B77024EB2 CRC64;
MCDRNGGRRL RQWLIEQIDS EQYPGLIWEN EEKTMFRIPW KHAGKQDYNQ EVDASIFKAW
AVFKGKFKEG DKAEPATWKT RLRCALNKSP DFEEVTDRSQ LDISEPYKVY RIVPEEEQKC
KIGVGNGSSL TDVGDMDCSP SAIDDLMKEP PCVDEYLGII KRSPSPPQET CRNPPIPDWW
MQQPSPSLPL VNGYTGYEQH HSGYSQMVIT FFYSGRLVGH ITTSYPEGCR LSLSQPSNHG
EKLYTPDSLE HVRFPSAEAI QNDRQKQITK KLFGHLERGV LLHSNKQGIF IKRLCQGRVF
WSGNTVVYKD RPSKLDRDEV VKIFDTNLFF RELQQYYNNQ GRFPDSRVML CFGEEFPDTV
PLRCKLILVQ VEQLCVRQVM EEAGKTCSSP MLPDDVQQEQ VYRIFQDICG PHQRPLFREN
QQIAV
