IRG7_CAEEL
ID IRG7_CAEEL Reviewed; 2217 AA.
AC A0A131MBU3; Q20219;
DT 10-MAY-2017, integrated into UniProtKB/Swiss-Prot.
DT 11-MAY-2016, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=Protein irg-7 {ECO:0000305};
DE AltName: Full=Infection response protein 7 {ECO:0000305};
DE Flags: Precursor;
GN Name=irg-7 {ECO:0000303|PubMed:28196094, ECO:0000312|WormBase:F40F4.6b};
GN Synonyms=drd-2 {ECO:0000312|WormBase:F40F4.6b},
GN upr-1 {ECO:0000312|WormBase:F40F4.6b};
GN ORFNames=F40F4.6 {ECO:0000312|WormBase:F40F4.6b};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, DEVELOPMENTAL STAGE, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28196094; DOI=10.1371/journal.pgen.1006577;
RA Yunger E., Safra M., Levi-Ferber M., Haviv-Chesner A., Henis-Korenblit S.;
RT "Innate immunity mediated longevity and longevity induced by germ cell
RT removal converge on the C-type lectin domain protein IRG-7.";
RL PLoS Genet. 13:E1006577-E1006577(2017).
CC -!- FUNCTION: Plays a role in innate immunity, probably via the atf-7
CC pathway, to confer resistance to pathogenic bacteria. May also play a
CC role in the regulation of longevity. {ECO:0000269|PubMed:28196094}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=b {ECO:0000312|WormBase:F40F4.6b};
CC IsoId=A0A131MBU3-1; Sequence=Displayed;
CC Name=a {ECO:0000312|WormBase:F40F4.6a};
CC IsoId=A0A131MBU3-2; Sequence=VSP_058914;
CC -!- DEVELOPMENTAL STAGE: Expressed in the posterior cells of the intestine
CC in L4 larva. {ECO:0000269|PubMed:28196094}.
CC -!- INDUCTION: Up-regulated following infection with P.luminescens subsp Hb
CC and E.faecalis bacteria. {ECO:0000269|PubMed:28196094}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown in larvae results in
CC reduced survival following infection with the pathogenic bacterium
CC P.luminescens. RNAi-mediated knockdown in a glp-1 e2141 mutant
CC background (in which germ cells are deleted) rescues the increased
CC lifespan phenotype of the glp-1 mutant. {ECO:0000269|PubMed:28196094}.
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DR EMBL; BX284606; CCD70146.2; -; Genomic_DNA.
DR EMBL; BX284606; CZR14621.1; -; Genomic_DNA.
DR PIR; T16305; T16305.
DR RefSeq; NP_001309693.1; NM_001322616.1.
DR RefSeq; NP_508552.2; NM_076151.4. [A0A131MBU3-2]
DR AlphaFoldDB; A0A131MBU3; -.
DR SMR; A0A131MBU3; -.
DR STRING; 6239.F40F4.6; -.
DR EnsemblMetazoa; F40F4.6a.1; F40F4.6a.1; WBGene00018237. [A0A131MBU3-2]
DR EnsemblMetazoa; F40F4.6b.1; F40F4.6b.1; WBGene00018237. [A0A131MBU3-1]
DR GeneID; 180613; -.
DR KEGG; cel:CELE_F40F4.6; -.
DR UCSC; F40F4.6; c. elegans.
DR CTD; 180613; -.
DR WormBase; F40F4.6a; CE47861; WBGene00018237; irg-7. [A0A131MBU3-2]
DR WormBase; F40F4.6b; CE51544; WBGene00018237; irg-7. [A0A131MBU3-1]
DR eggNOG; ENOG502SD0F; Eukaryota.
DR GeneTree; ENSGT01030000234566; -.
DR OMA; WGGPIAE; -.
DR OrthoDB; 1016037at2759; -.
DR PRO; PR:A0A131MBU3; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00018237; Expressed in larva and 3 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR Gene3D; 3.10.100.10; -; 1.
DR Gene3D; 3.40.50.410; -; 1.
DR InterPro; IPR001304; C-type_lectin-like.
DR InterPro; IPR016186; C-type_lectin-like/link_sf.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR006582; MD_domain.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR Pfam; PF00059; Lectin_C; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00034; CLECT; 1.
DR SMART; SM00181; EGF; 3.
DR SMART; SM00604; MD; 2.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; SSF53300; 1.
DR SUPFAM; SSF56436; SSF56436; 1.
DR PROSITE; PS50041; C_TYPE_LECTIN_2; 1.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS50234; VWFA; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Disulfide bond; EGF-like domain; Immunity;
KW Innate immunity; Lectin; Reference proteome; Repeat; Secreted; Signal.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..2217
FT /note="Protein irg-7"
FT /evidence="ECO:0000305"
FT /id="PRO_5007283654"
FT DOMAIN 370..405
FT /note="EGF-like 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 864..896
FT /note="EGF-like 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 1188..1313
FT /note="C-type lectin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DOMAIN 1499..1533
FT /note="EGF-like 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DOMAIN 2016..2202
FT /note="VWFA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00219"
FT DISULFID 379..393
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 395..404
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 868..873
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 886..895
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1212..1312
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 1285..1304
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00040"
FT DISULFID 1508..1521
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT DISULFID 1523..1532
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT VAR_SEQ 58..60
FT /note="Missing (in isoform a)"
FT /evidence="ECO:0000305"
FT /id="VSP_058914"
SQ SEQUENCE 2217 AA; 243736 MW; 137AB95B7D8F880D CRC64;
MRNWVLIAAL AVICLATEQE LSHKDRIRAV LRSWSPASQK QFFEPVREQK YRTMEERVIF
LDTHHISKRS IAEPHVLAGM ATRGCNKPGY TGETCQYPLC SARNPYIPNN DGFDDIAIDA
YNLANCSESY IVVVDETMRN IKIEVETASA LNPTFYLQAE NGDLIFPDES IQLPTMFTAN
YLHLPPGQYM LGPRADTSEQ FCTMMMSSRS SIHVSGGFTS GDQAERSDYP NLKFTYFDTE
SVVAIHAQGL DFPGQIQAIG FTGAENHISR YIPMTTRFNC TYPYILERYT CRKTSNNDAG
HNLIQVEGVT NSGYKFRRIV PYQCVLPPVT TTTPAVPTTP AAPITSCQNG GQLLTDSNGV
AYCYCFGLYS GSTCSQMLCA NGGFLPTPTS DRCQCPEGFS GFHCQNILCT DMSGFDFNAE
NPTLTLVIRS RSQLSAVIEQ ATESVQSIVD LLASEPGYLS KFIVVLFDNG KLLVNRQYDS
WDAAMVDLTK AIHSAPSEGG CDDVVMSAVA SALSLYPTNK SPIYVITDAT PNDSAEKETV
FHLESYWRAP IYFIYVQPSP ADGCNSSPDN SAYRDMVDMA ARSSGNTFYF SDRSTISTFF
YRHMLNTLFR SQLVLSGDYS HCSSQNLYKS AAFDLSVDYV TIVATGTNLT LVVTSPTGQY
PTFNTAFSDG VNYVWTYNSP VAGQWFFSIR SLEPEAACTF KVYQKKFNFG GQTQYSPDYD
IFWSFASTLT SAAGVLRQPV LGFDSSPVFH VTNYPQFLSM DRVHANLQIY AIRDGVQTEV
YGSSGMYRDA CEFNFYFPPF TCRVPEEVLY FNFFARDNND MALQRAGTMF CAAVHPTPPP
DHQCQNGGVM NPSNTTCFCT PEFTGTYCQN IICYNGGTAS GDHCVCPPGY AGESCEMARC
IETGPNPEFI RYGVDMVFAV EITQNSIASL SMLNINFQEI LRDVLMQNRG WIRNFVLVGF
NSTWGGPIAE SPADNLTAIT TALRTLASSV PADTGCTVKL WDALNYAIFS RQMAPGSFVE
IFQTTPEDDT DTRSLGLFYD MSRTMELVLY GFLTSNPRLQ PEGFVCNATV ENYYTLLGIV
SGSTGTTYSL QANEISNAVR LIPLQFSNGQ VTFNALDDCR HDDGLITYFP VDAYTQTIQI
QTFGYGTTIQ VYTGAGVMAE ALELFYDDFT GQSVYEIRKA CDEGWEPIGQ YCIKFMATVE
NILPMPQAKA FCASAGGFLV DDLTDDKNGF LKSVAANTQF WTGLFKNNDG QFYWDRGTGI
NPDLLNQPIT YWADGEPSDD PTRQCVYFNG RSGDANKVWT TDTCAEPRAF ACQKHRYDAD
HRPNVIGDDD LPAGWWYAKV KSNPPSGYPN MCTMSVRVQS SLQIVTGFST KIGNDFPLPD
PIQDSTENRL ISYVHSVDNE NRVPILTDAI LWDAYNGTFY NGLKYQVRFG CQFAWVTQDF
PCPNGDSQAN EFGVLHVGED EFGNTFQRLT FGHCSRAQIT CGNGGIRQNG QCVCTDYWTG
SRCTVPICVN GGTRNPDEAT CSCPDGYEGP NCQFEVCQPN VPQLFSNDRK SLLMVVETTR
QNSDTVNQLI ANLKNIVSAV TNNMPLWFTN FGLVTFDTTG RTFEKFDYTS IDDLITDLTT
QSNAISTDGV CSMPYLGVLA HLLEHDDVIA MPNSEIFLVT PAGPSDLGNY VETMEVLFNT
QAHLHYVVSK TANCATFDGV NNVRDMTWLG YGSSGNILFT DPANIVNLFN SYLPTLYGAS
VLQDPTGITN YTCSDGSLPW FVPVDINTTF IYVTTSAEFG SLSVKDPLGA AHSATPVYNV
NDQKIYAIEV DRLGGIWTLQ LVQPPGLCLA HVYSTGGAKV YTKFSMPNPI GGKPDPLGSH
QDGRFVQPTA GFDNVAVFHL AGNPFHRGQL QYVEIFDIGA NSITNILRSE LYVRAGCSYE
YYSDLFTCNG DMIAVYVHGV DEANQKFRRQ EIVICNGRSP TTNQPATGTI GPITMPTQQT
ALTQGPVTQQ TQVPGTQPTQ GPVATTQNPY TSAQFDVVFM IDGSQSAQSS FDSLTKFVQT
FMVSFNVGQS GARVGLIVVG GDITNPIPPA ANLNSLSSQA MLNSNLAQLS GGYTDFEDAG
QILNYTLQIV SSPDFMAANN GYRSGISNHV LIYLTTTTAF DTDPTPAAQT ILAQKQYGII
TIGYGGATDN NKLQTISGGS ACSFTAPDFA SLNNQIKTIQ QLILNANANG GVYCINN
