ID   IRGA_VIBCH              Reviewed;         652 AA.
AC   P0C6R0; P27772; Q9KUP0;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Iron-regulated outer membrane virulence protein;
DE   Flags: Precursor;
GN   Name=irgA; OrderedLocusNames=VC_0475;
OS   Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=243277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 39315 / El Tor Inaba N16961;
RX   PubMed=10952301; DOI=10.1038/35020000;
RA   Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L.,
RA   Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R.,
RA   Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D.,
RA   Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A.,
RA   Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L.,
RA   Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.;
RT   "DNA sequence of both chromosomes of the cholera pathogen Vibrio
RT   cholerae.";
RL   Nature 406:477-483(2000).
CC   -!- FUNCTION: Involved in the initial step of iron uptake by binding ferric
CC       vibriobactin, an iron chelatin siderophore that allows V.cholerae to
CC       extract iron from the environment. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TonB-dependent receptor family.
CC       {ECO:0000305}.
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DR   EMBL; AE003852; AAF93648.1; -; Genomic_DNA.
DR   PIR; D82317; D82317.
DR   RefSeq; NP_230129.1; NC_002505.1.
DR   RefSeq; WP_000086048.1; NZ_LT906614.1.
DR   AlphaFoldDB; P0C6R0; -.
DR   SMR; P0C6R0; -.
DR   STRING; 243277.VC_0475; -.
DR   DNASU; 2615269; -.
DR   EnsemblBacteria; AAF93648; AAF93648; VC_0475.
DR   GeneID; 57739221; -.
DR   KEGG; vch:VC_0475; -.
DR   PATRIC; fig|243277.26.peg.449; -.
DR   eggNOG; COG4771; Bacteria.
DR   HOGENOM; CLU_008287_18_2_6; -.
DR   OMA; PDKEKMM; -.
DR   BioCyc; VCHO:VC0475-MON; -.
DR   Proteomes; UP000000584; Chromosome 1.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031230; C:intrinsic component of cell outer membrane; IBA:GO_Central.
DR   GO; GO:0015344; F:siderophore uptake transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055072; P:iron ion homeostasis; IEA:UniProtKB-KW.
DR   GO; GO:0071702; P:organic substance transport; IEA:UniProt.
DR   GO; GO:0044718; P:siderophore transmembrane transport; IBA:GO_Central.
DR   Gene3D; 2.170.130.10; -; 1.
DR   Gene3D; 2.40.170.20; -; 1.
DR   InterPro; IPR039426; BtuB-like.
DR   InterPro; IPR012910; Plug_dom.
DR   InterPro; IPR037066; Plug_dom_sf.
DR   InterPro; IPR000531; TonB-dep_rcpt_b-brl.
DR   InterPro; IPR010916; TonB_box_CS.
DR   InterPro; IPR036942; TonB_rcpt_b-brl_sf.
DR   InterPro; IPR010917; TonB_rcpt_CS.
DR   PANTHER; PTHR30069; PTHR30069; 1.
DR   Pfam; PF07715; Plug; 1.
DR   Pfam; PF00593; TonB_dep_Rec; 1.
DR   PROSITE; PS00430; TONB_DEPENDENT_REC_1; 1.
DR   PROSITE; PS01156; TONB_DEPENDENT_REC_2; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Ion transport; Iron; Iron transport; Membrane;
KW   Receptor; Reference proteome; Signal; TonB box; Transmembrane;
KW   Transmembrane beta strand; Transport; Virulence.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..652
FT                   /note="Iron-regulated outer membrane virulence protein"
FT                   /id="PRO_0000034764"
FT   MOTIF           33..40
FT                   /note="TonB box"
FT   MOTIF           635..652
FT                   /note="TonB C-terminal box"
SQ   SEQUENCE   652 AA;  71669 MW;  A95F82FEC072EC93 CRC64;
     MSRFNPSPVS LSVTLGLMFS ASAFAQDATK TDETMVVTAA GYAQVIQNAP ASISVISRED
     LESRYYRDVT DALKSVPGVT VTGGGDTTDI SIRGMGSNYT LILVDGKRQT SRQTRPNSDG
     PGIEQGWLPP LQAIERIEVI RGPMSTLYGS DAIGGVINII TRKDQQQWSG NVQLSTVVQE
     NRASGDEQSA NFFVTGPLSD ALSLQVYGQT TQRDEDEIEH GYGDKSLRSL TSKLNYQLNP
     DHQLQLEAGV SAQDRENNVG KSAQSSGCRG TCSNTDNQYR RNHVAVSHQG DWQDVGQSDT
     YLQYEENTNK SREMSIDNTV FKSTLVAPIG EHMLSFGVEG KHESLEDKTS NKISSRTHIS
     NTQWAGFIED EWALAEQFRL TFGGRLDHDK NYGSHFSPRV YGVWNLDPLW TVKGGVSTGF
     RAPQLREVTP DWGQVSGGGN IYGNPDLKPE TSINKELSLM YSTGSGLAAS LTAFHNDFKD
     KITRVACPAN ICTAGPNQWG AAPTYRVNID EAETYGAEAT LSLPITESVE LSSSYTYTHS
     EQKSGNFAGR PLLQLPKHLF NANLSWQTTD RLNSWANLNY RGKEMQPEGG ASNDDFIAPS
     YTFIDTGVTY ALTDTATIKA AVYNLFDQEV NYAEYGYVED GRRYWLGLDI AF