APRL4_ARATH
ID APRL4_ARATH Reviewed; 310 AA.
AC Q9SA00; B3H6M4;
DT 02-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=5'-adenylylsulfate reductase-like 4;
DE AltName: Full=Adenosine 5'-phosphosulfate reductase-like 4;
DE Short=APR-like 4;
DE Short=AtAPRL4;
DE Flags: Precursor;
GN Name=APRL4; OrderedLocusNames=At1g34780; ORFNames=F11O6.7, F21H2.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9SA00-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SA00-2; Sequence=VSP_039984;
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DR EMBL; AC007894; AAD46003.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31738.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE31739.1; -; Genomic_DNA.
DR EMBL; AY059876; AAL24358.1; -; mRNA.
DR EMBL; AY093358; AAM13357.1; -; mRNA.
DR RefSeq; NP_001117412.1; NM_001123940.1. [Q9SA00-2]
DR RefSeq; NP_564452.1; NM_103198.3. [Q9SA00-1]
DR AlphaFoldDB; Q9SA00; -.
DR BioGRID; 25614; 5.
DR IntAct; Q9SA00; 6.
DR STRING; 3702.AT1G34780.1; -.
DR PaxDb; Q9SA00; -.
DR PRIDE; Q9SA00; -.
DR ProteomicsDB; 240600; -. [Q9SA00-1]
DR EnsemblPlants; AT1G34780.1; AT1G34780.1; AT1G34780. [Q9SA00-1]
DR EnsemblPlants; AT1G34780.2; AT1G34780.2; AT1G34780. [Q9SA00-2]
DR GeneID; 840382; -.
DR Gramene; AT1G34780.1; AT1G34780.1; AT1G34780. [Q9SA00-1]
DR Gramene; AT1G34780.2; AT1G34780.2; AT1G34780. [Q9SA00-2]
DR KEGG; ath:AT1G34780; -.
DR Araport; AT1G34780; -.
DR TAIR; locus:2008366; AT1G34780.
DR eggNOG; KOG2640; Eukaryota.
DR OMA; CNSLKEP; -.
DR OrthoDB; 1057290at2759; -.
DR PhylomeDB; Q9SA00; -.
DR PRO; PR:Q9SA00; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SA00; baseline and differential.
DR Genevisible; Q9SA00; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR044606; APRL4/6.
DR InterPro; IPR036249; Thioredoxin-like_sf.
DR InterPro; IPR013766; Thioredoxin_domain.
DR PANTHER; PTHR46854; PTHR46854; 1.
DR Pfam; PF00085; Thioredoxin; 1.
DR SUPFAM; SSF52833; SSF52833; 1.
DR PROSITE; PS51352; THIOREDOXIN_2; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Membrane; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..310
FT /note="5'-adenylylsulfate reductase-like 4"
FT /id="PRO_0000400041"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 49..168
FT /note="Thioredoxin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00691"
FT CARBOHYD 143
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 190
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 97..125
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_039984"
SQ SEQUENCE 310 AA; 35008 MW; 79F3763AF77365E5 CRC64;
MEKEILLLLL VIMFLTVADV DAVRVPFCAT KSAKDSIFGL RDQTCSVSGV ESDERPRFVA
VTEGDERWLQ IALDMIHKNK CDYVALLFYA SWCPFSRSFR PSFDVISSLY SSIPHFAIKE
SSIKPSTLSK YGVHGFPTLL LLNSTMRARY RGTRMLDSLV AFYSDVTGIE TLDKTSLERS
VSVPHLGNEN NTEPENCPFT WARSPENMLR QETYLALAIV FVLLRLLHLI YPTLVVFMKF
TWRRIAQNMR LESLLEHTVG FLSRAVQLCM HRRSNLQGGA MNARAWASKS LATVSIGDSS
SSNRRSSSSQ
