ID   IRGQ_HUMAN              Reviewed;         623 AA.
AC   Q8WZA9; B2RNP3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Immunity-related GTPase family Q protein;
GN   Name=IRGQ; Synonyms=IRGQ1; ORFNames=FKSG27;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang Y.-G., Gong L.;
RT   "Molecular cloning of FKSG27, a novel gene related to cervical tumor.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   PROTEIN SEQUENCE OF 2-20; 166-176; 178-214; 389-401; 533-544 AND 596-609,
RP   AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Fetal brain cortex;
RA   Lubec G., Chen W.-Q., Sun Y.;
RL   Submitted (DEC-2008) to UniProtKB.
RN   [5]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-203, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [6]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Liver;
RX   PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA   Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA   Ye M., Zou H.;
RT   "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT   phosphoproteome.";
RL   J. Proteomics 96:253-262(2014).
CC   -!- INTERACTION:
CC       Q8WZA9; Q9H492: MAP1LC3A; NbExp=3; IntAct=EBI-1055331, EBI-720768;
CC       Q8WZA9; Q9GZQ8: MAP1LC3B; NbExp=3; IntAct=EBI-1055331, EBI-373144;
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. IRG family. {ECO:0000255|PROSITE-ProRule:PRU01053,
CC       ECO:0000305}.
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DR   EMBL; AF322648; AAL33884.1; -; mRNA.
DR   EMBL; CH471126; EAW57205.1; -; Genomic_DNA.
DR   EMBL; BC137020; AAI37021.1; -; mRNA.
DR   EMBL; BC137021; AAI37022.1; -; mRNA.
DR   CCDS; CCDS33040.1; -.
DR   RefSeq; NP_001007562.1; NM_001007561.2.
DR   RefSeq; XP_005258572.1; XM_005258515.3.
DR   AlphaFoldDB; Q8WZA9; -.
DR   BioGRID; 125975; 21.
DR   IntAct; Q8WZA9; 17.
DR   STRING; 9606.ENSP00000387535; -.
DR   GlyGen; Q8WZA9; 1 site, 1 O-linked glycan (1 site).
DR   iPTMnet; Q8WZA9; -.
DR   MetOSite; Q8WZA9; -.
DR   PhosphoSitePlus; Q8WZA9; -.
DR   BioMuta; IRGQ; -.
DR   DMDM; 74751646; -.
DR   EPD; Q8WZA9; -.
DR   jPOST; Q8WZA9; -.
DR   MassIVE; Q8WZA9; -.
DR   MaxQB; Q8WZA9; -.
DR   PaxDb; Q8WZA9; -.
DR   PeptideAtlas; Q8WZA9; -.
DR   PRIDE; Q8WZA9; -.
DR   ProteomicsDB; 75248; -.
DR   Antibodypedia; 48982; 103 antibodies from 19 providers.
DR   DNASU; 126298; -.
DR   Ensembl; ENST00000422989.6; ENSP00000387535.1; ENSG00000167378.10.
DR   Ensembl; ENST00000602269.2; ENSP00000472250.1; ENSG00000167378.10.
DR   GeneID; 126298; -.
DR   KEGG; hsa:126298; -.
DR   MANE-Select; ENST00000422989.6; ENSP00000387535.1; NM_001007561.3; NP_001007562.1.
DR   UCSC; uc002oww.3; human.
DR   CTD; 126298; -.
DR   GeneCards; IRGQ; -.
DR   HGNC; HGNC:24868; IRGQ.
DR   HPA; ENSG00000167378; Tissue enhanced (brain).
DR   neXtProt; NX_Q8WZA9; -.
DR   OpenTargets; ENSG00000167378; -.
DR   PharmGKB; PA142671653; -.
DR   VEuPathDB; HostDB:ENSG00000167378; -.
DR   eggNOG; ENOG502RY8G; Eukaryota.
DR   GeneTree; ENSGT00510000048991; -.
DR   HOGENOM; CLU_037636_0_0_1; -.
DR   InParanoid; Q8WZA9; -.
DR   OMA; RTHFPGP; -.
DR   OrthoDB; 844397at2759; -.
DR   PhylomeDB; Q8WZA9; -.
DR   TreeFam; TF331897; -.
DR   PathwayCommons; Q8WZA9; -.
DR   SignaLink; Q8WZA9; -.
DR   BioGRID-ORCS; 126298; 8 hits in 1074 CRISPR screens.
DR   ChiTaRS; IRGQ; human.
DR   GenomeRNAi; 126298; -.
DR   Pharos; Q8WZA9; Tdark.
DR   PRO; PR:Q8WZA9; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q8WZA9; protein.
DR   Bgee; ENSG00000167378; Expressed in type B pancreatic cell and 202 other tissues.
DR   ExpressionAtlas; Q8WZA9; baseline and differential.
DR   Genevisible; Q8WZA9; HS.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   InterPro; IPR030385; G_IRG_dom.
DR   InterPro; IPR040070; IRGQ.
DR   PANTHER; PTHR19364; PTHR19364; 1.
DR   PROSITE; PS51716; G_IRG; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Direct protein sequencing; Phosphoprotein; Reference proteome.
FT   CHAIN           1..623
FT                   /note="Immunity-related GTPase family Q protein"
FT                   /id="PRO_0000264463"
FT   DOMAIN          223..449
FT                   /note="IRG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01053"
FT   REGION          334..393
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          155..180
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        334..350
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         203
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0007744|PubMed:18669648"
SQ   SEQUENCE   623 AA;  62717 MW;  6D7231134A3A799B CRC64;
     MPPPQGDVTA LFLGPPGLGK SALIAALCDK DVETLEAPEG RPDSGVPSLR AAGPGLFLGE
     LSCPPAAPGP WAAEANVLVL VLPGPEGNGE PLAPALGEAA LAALARGTPL LAVRNLRPGD
     SQTAAQARDQ TAALLNSAGL GAADLFVLPA NCGSSDGCEE LERLRAALQS QAEALRRLLP
     PAQDGFEVLG AAELEAVREA FETGGLEAAL SWVRSGLERL GSARLDLAVA GKADVGLVVD
     MLLGLDPGDP GAAPASVPTA PTPFPAPERP NVVLWTVPLG HTGTATTAAA ASHPTHYDAL
     ILVTPGAPTE KDWAQVQALL LPDAPLVCVR TDGEGEDPEC LGEGKMENPK GESLKNAGGG
     GLENALSKGR EKCSAGSQKA GSGEGPGKAG SEGLQQVVGM KKSGGGDSER AAALSPEDET
     WEVLEEAPPP VFPLRPGGLP GLCEWLRRAL PPAQAGALLL ALPPASPSAA RTKAAALRAG
     AWRPALLASL AAAAAPLPGL GWACDVALLR GQLAEWRRGL GLEPTALARR ERALGLASGE
     LAARAHFPGP VTRAEVEARL GAWAGEGTAG GAALGALSFL WPAGGAAATG GLGYRAAHGV
     LLQALDEMRA DAEAVLAPPE PAQ