ID   IRGQ_MOUSE              Reviewed;         583 AA.
AC   Q8VIM9; Q7TNC7;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=Immunity-related GTPase family Q protein;
GN   Name=Irgq; Synonyms=Irgq1; ORFNames=Fksg27;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Wang Y.-G., Gong L.;
RT   "Molecular cloning of FKSG27, a novel gene related to cervical tumor.";
RL   Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain, Liver, and Spleen;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SIMILARITY: Belongs to the TRAFAC class dynamin-like GTPase
CC       superfamily. IRG family. {ECO:0000255|PROSITE-ProRule:PRU01053,
CC       ECO:0000305}.
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DR   EMBL; AF322649; AAL33885.1; -; mRNA.
DR   EMBL; BC056347; AAH56347.1; -; mRNA.
DR   EMBL; BC080294; AAH80294.1; -; mRNA.
DR   CCDS; CCDS20953.1; -.
DR   RefSeq; NP_694774.3; NM_153134.3.
DR   AlphaFoldDB; Q8VIM9; -.
DR   SMR; Q8VIM9; -.
DR   BioGRID; 229136; 7.
DR   STRING; 10090.ENSMUSP00000036699; -.
DR   iPTMnet; Q8VIM9; -.
DR   PhosphoSitePlus; Q8VIM9; -.
DR   EPD; Q8VIM9; -.
DR   MaxQB; Q8VIM9; -.
DR   PaxDb; Q8VIM9; -.
DR   PeptideAtlas; Q8VIM9; -.
DR   PRIDE; Q8VIM9; -.
DR   ProteomicsDB; 269096; -.
DR   Antibodypedia; 48982; 103 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000049020; ENSMUSP00000036699; ENSMUSG00000041037.
DR   GeneID; 210146; -.
DR   KEGG; mmu:210146; -.
DR   UCSC; uc009fpv.2; mouse.
DR   CTD; 126298; -.
DR   MGI; MGI:2667176; Irgq.
DR   VEuPathDB; HostDB:ENSMUSG00000041037; -.
DR   eggNOG; ENOG502RY8G; Eukaryota.
DR   GeneTree; ENSGT00510000048991; -.
DR   HOGENOM; CLU_037636_0_0_1; -.
DR   InParanoid; Q8VIM9; -.
DR   OMA; RTHFPGP; -.
DR   OrthoDB; 844397at2759; -.
DR   PhylomeDB; Q8VIM9; -.
DR   TreeFam; TF331897; -.
DR   BioGRID-ORCS; 210146; 3 hits in 72 CRISPR screens.
DR   ChiTaRS; Irgq; mouse.
DR   PRO; PR:Q8VIM9; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q8VIM9; protein.
DR   Bgee; ENSMUSG00000041037; Expressed in floor plate of midbrain and 223 other tissues.
DR   Genevisible; Q8VIM9; MM.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   InterPro; IPR030385; G_IRG_dom.
DR   InterPro; IPR040070; IRGQ.
DR   PANTHER; PTHR19364; PTHR19364; 2.
DR   PROSITE; PS51716; G_IRG; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Phosphoprotein; Reference proteome.
FT   CHAIN           1..583
FT                   /note="Immunity-related GTPase family Q protein"
FT                   /id="PRO_0000264464"
FT   DOMAIN          223..409
FT                   /note="IRG-type G"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01053"
FT   REGION          322..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          155..179
FT                   /evidence="ECO:0000255"
FT   MOD_RES         203
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WZA9"
FT   CONFLICT        510
FT                   /note="P -> T (in Ref. 2; AAH56347)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   583 AA;  59323 MW;  2DDB615708C9E596 CRC64;
     MPLPQGDVTA LFLGPPGSGK SALIAALCGK NVDTVEIPDG RQDSGVPSLR AAAPGLFLGE
     LSCPPAAPGP WAAEANLLVL VLPGSEGSEE PLTPALGEAA RAALARGTPL LAVRNLRPGD
     SQNAAKARDE TAALLNSAGL GAAPLFVPPA DCSSSDRCEE LERLQVVLRT QAEALQRLLP
     PAQDGFEVLG AAELEAVREA FETGGLEAAL SWVRAGLERL GSARLDLAVA GTTNVGLVLD
     MLLGLDPGDP GAAPASAPTG PTPYPAPERP NVVLWTVPLG PTATSPAVTP HPTHYDALIL
     VTPGAPTEEN WAQVRSLVSP DAPLVGVRTD GQGEDPPEVL EEEKAQNASD GNSGDARSEG
     KKAGIGDSGC TAARSPEDEL WEVLEEAPPP VFPMRPGGLP GLGTWLQHAL PTAQAGALLL
     ALPPASPRAA RRKAAALRAG AWRPALLASL AAAAAPVPGL GWACDVALLR GQLAEWRRAL
     GLEPAAVARR ERALGLAPGV LATRTRFPGP VTRAEVEARL GSWAGEGTAG GAALSALSFL
     WPTGGAAATG GLGYRAAHGV LLQALDEMLA DAEAVLGPPE PNQ