IRLR_BURP2
ID IRLR_BURP2 Reviewed; 229 AA.
AC I1WSZ4; O31395; Q63LH5;
DT 09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2012, sequence version 1.
DT 03-AUG-2022, entry version 42.
DE RecName: Full=Transcriptional activator protein IrlR;
GN Name=irlR; OrderedLocusNames=BP1026B_II1139;
OS Burkholderia pseudomallei (strain 1026b).
OC Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia; pseudomallei group.
OX NCBI_TaxID=884204;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=1026b;
RX PubMed=9393784; DOI=10.1128/iai.65.12.4972-4977.1997;
RA Jones A.L., Deshazer D., Woods D.E.;
RT "Identification and characterization of a two-component regulatory system
RT involved in invasion of eukaryotic cells and heavy-metal resistance in
RT Burkholderia pseudomallei.";
RL Infect. Immun. 65:4972-4977(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1026b;
RX PubMed=22615773; DOI=10.1371/journal.pone.0036507;
RA Hayden H.S., Lim R., Brittnacher M.J., Sims E.H., Ramage E.R., Fong C.,
RA Wu Z., Crist E., Chang J., Zhou Y., Radey M., Rohmer L., Haugen E.,
RA Gillett W., Wuthiekanun V., Peacock S.J., Kaul R., Miller S.I., Manoil C.,
RA Jacobs M.A.;
RT "Evolution of Burkholderia pseudomallei in recurrent melioidosis.";
RL PLoS ONE 7:E36507-E36507(2012).
CC -!- FUNCTION: Member of the two-component regulatory system IrlR/IrlS. May
CC be involved in invasion of eukaryotic cells and heavy-metal resistance.
CC -!- PTM: Phosphorylated by IrlS. {ECO:0000305}.
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DR EMBL; AF005358; AAB92482.1; -; Genomic_DNA.
DR EMBL; CP002834; AFI69388.1; -; Genomic_DNA.
DR RefSeq; WP_004197868.1; NZ_CP004380.1.
DR AlphaFoldDB; I1WSZ4; -.
DR SMR; I1WSZ4; -.
DR EnsemblBacteria; AFI69388; AFI69388; BP1026B_II1139.
DR GeneID; 56597413; -.
DR KEGG; bpz:BP1026B_II1139; -.
DR PATRIC; fig|884204.3.peg.5416; -.
DR Proteomes; UP000010087; Chromosome 2.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR006291; PcoR.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR039420; WalR-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR48111; PTHR48111; 1.
DR Pfam; PF00072; Response_reg; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00448; REC; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR TIGRFAMs; TIGR01387; cztR_silR_copR; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW Activator; Cadmium; DNA-binding; Phosphoprotein; Transcription;
KW Transcription regulation; Two-component regulatory system; Zinc.
FT CHAIN 1..229
FT /note="Transcriptional activator protein IrlR"
FT /id="PRO_0000429790"
FT DOMAIN 2..115
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DNA_BIND 123..221
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT MOD_RES 51
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT CONFLICT 16
FT /note="L -> V (in Ref. 1; AAB92482)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 229 AA; 25985 MW; 9DC97F0F2FC83887 CRC64;
MRILIVEDEP KTGMYLRKGL TEAGFIADWV EDGVTGLHQA ETEEYDLIIL DVMLPGHDGW
TVLERLRRAH STPVLFLTAR DDVGDRVKGL ELGADDYVVK PFDFVELVAR VRSILRRGQA
RESTVLRIAD LELDLTRRKA TRQGDVVLLT AKEFALLWLL MRREGEILPR ATIASQVWDM
NFNSDTNVVD AAIRRLRSKI DDAYEPKLIH TVRGMGYVLE VRSASAPSR
