ID   IRLR_BURPS              Reviewed;         229 AA.
AC   P0DMK7; O31395; Q63LH5;
DT   09-JUL-2014, integrated into UniProtKB/Swiss-Prot.
DT   09-JUL-2014, sequence version 1.
DT   03-AUG-2022, entry version 33.
DE   RecName: Full=Transcriptional activator protein IrlR;
GN   Name=irlR; OrderedLocusNames=BPSS1040;
OS   Burkholderia pseudomallei (strain K96243).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Burkholderia; pseudomallei group.
OX   NCBI_TaxID=272560;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K96243;
RX   PubMed=15377794; DOI=10.1073/pnas.0403302101;
RA   Holden M.T.G., Titball R.W., Peacock S.J., Cerdeno-Tarraga A.-M.,
RA   Atkins T., Crossman L.C., Pitt T., Churcher C., Mungall K.L., Bentley S.D.,
RA   Sebaihia M., Thomson N.R., Bason N., Beacham I.R., Brooks K., Brown K.A.,
RA   Brown N.F., Challis G.L., Cherevach I., Chillingworth T., Cronin A.,
RA   Crossett B., Davis P., DeShazer D., Feltwell T., Fraser A., Hance Z.,
RA   Hauser H., Holroyd S., Jagels K., Keith K.E., Maddison M., Moule S.,
RA   Price C., Quail M.A., Rabbinowitsch E., Rutherford K., Sanders M.,
RA   Simmonds M., Songsivilai S., Stevens K., Tumapa S., Vesaratchavest M.,
RA   Whitehead S., Yeats C., Barrell B.G., Oyston P.C.F., Parkhill J.;
RT   "Genomic plasticity of the causative agent of melioidosis, Burkholderia
RT   pseudomallei.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:14240-14245(2004).
CC   -!- FUNCTION: Member of the two-component regulatory system IrlR/IrlS. May
CC       be involved in invasion of eukaryotic cells and heavy-metal resistance
CC       (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated by IrlS. {ECO:0000250}.
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DR   EMBL; BX571966; CAH38501.1; -; Genomic_DNA.
DR   RefSeq; WP_004197868.1; NZ_CP009537.1.
DR   RefSeq; YP_111046.1; NC_006351.1.
DR   AlphaFoldDB; P0DMK7; -.
DR   SMR; P0DMK7; -.
DR   STRING; 272560.BPSS1040; -.
DR   EnsemblBacteria; CAH38501; CAH38501; BPSS1040.
DR   GeneID; 56597413; -.
DR   KEGG; bps:BPSS1040; -.
DR   PATRIC; fig|272560.51.peg.4228; -.
DR   eggNOG; COG0745; Bacteria.
DR   OMA; YGQDDAH; -.
DR   Proteomes; UP000000605; Chromosome 2.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00383; trans_reg_C; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR006291; PcoR.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR039420; WalR-like.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR48111; PTHR48111; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM00448; REC; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   TIGRFAMs; TIGR01387; cztR_silR_copR; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   Activator; Cadmium; DNA-binding; Phosphoprotein; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system;
KW   Zinc.
FT   CHAIN           1..229
FT                   /note="Transcriptional activator protein IrlR"
FT                   /id="PRO_0000081112"
FT   DOMAIN          2..115
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DNA_BIND        123..221
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
FT   MOD_RES         51
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
SQ   SEQUENCE   229 AA;  25985 MW;  9DC97F0F2FC83887 CRC64;
     MRILIVEDEP KTGMYLRKGL TEAGFIADWV EDGVTGLHQA ETEEYDLIIL DVMLPGHDGW
     TVLERLRRAH STPVLFLTAR DDVGDRVKGL ELGADDYVVK PFDFVELVAR VRSILRRGQA
     RESTVLRIAD LELDLTRRKA TRQGDVVLLT AKEFALLWLL MRREGEILPR ATIASQVWDM
     NFNSDTNVVD AAIRRLRSKI DDAYEPKLIH TVRGMGYVLE VRSASAPSR