IRO1_CANAL
ID IRO1_CANAL Reviewed; 596 AA.
AC Q5AJ77; A0A1D8PJ51;
DT 19-MAR-2014, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 68.
DE RecName: Full=Transcription factor IRO1;
DE AltName: Full=Iron utilization protein 1;
GN Name=IRO1; OrderedLocusNames=CAALFM_C301360CA;
GN ORFNames=CaO19.1715, CaO19.9283;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP FUNCTION.
RX PubMed=11223939;
RX DOI=10.1002/1097-0061(20010315)18:4<301::aid-yea672>3.0.co;2-h;
RA Garcia M.G., O'Connor J.E., Garcia L.L., Martinez S.I., Herrero E.,
RA del Castillo Agudo L.;
RT "Isolation of a Candida albicans gene, tightly linked to URA3, coding for a
RT putative transcription factor that suppresses a Saccharomyces cerevisiae
RT aft1 mutation.";
RL Yeast 18:301-311(2001).
RN [5]
RP INDUCTION.
RX PubMed=15387822; DOI=10.1111/j.1365-2958.2004.04214.x;
RA Lan C.Y., Rodarte G., Murillo L.A., Jones T., Davis R.W., Dungan J.,
RA Newport G., Agabian N.;
RT "Regulatory networks affected by iron availability in Candida albicans.";
RL Mol. Microbiol. 53:1451-1469(2004).
RN [6]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16237272; DOI=10.1111/j.1348-0421.2005.tb03686.x;
RA Chibana H., Uno J., Cho T., Mikami Y.;
RT "Mutation in IRO1 tightly linked with URA3 gene reduces virulence of
RT Candida albicans.";
RL Microbiol. Immunol. 49:937-939(2005).
CC -!- FUNCTION: Transcription factor involved in iron utilization and
CC virulence. {ECO:0000269|PubMed:11223939, ECO:0000269|PubMed:16237272}.
CC -!- INDUCTION: Expression is increased with increased iron.
CC {ECO:0000269|PubMed:15387822}.
CC -!- DISRUPTION PHENOTYPE: Decreases virulence.
CC {ECO:0000269|PubMed:16237272}.
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DR EMBL; CP017625; AOW28179.1; -; Genomic_DNA.
DR RefSeq; XP_721786.1; XM_716693.1.
DR AlphaFoldDB; Q5AJ77; -.
DR STRING; 237561.Q5AJ77; -.
DR PRIDE; Q5AJ77; -.
DR GeneID; 3636648; -.
DR KEGG; cal:CAALFM_C301360CA; -.
DR CGD; CAL0000179014; IRO1.
DR VEuPathDB; FungiDB:C3_01360C_A; -.
DR HOGENOM; CLU_457809_0_0_1; -.
DR OMA; NDAEVNT; -.
DR OrthoDB; 1685884at2759; -.
DR PHI-base; PHI:514; -.
DR PRO; PR:Q5AJ77; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0006879; P:cellular iron ion homeostasis; IMP:CGD.
PE 2: Evidence at transcript level;
KW Reference proteome; Transcription; Transcription regulation; Virulence.
FT CHAIN 1..596
FT /note="Transcription factor IRO1"
FT /id="PRO_0000425796"
FT REGION 25..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 378..411
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..84
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..403
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 596 AA; 65364 MW; C73BD691854EBA93 CRC64;
MLDRLNRKQS KERFVNKIPI STTKIDKSLE HTRRDDESNN AKRGVNPDES YSSDTSFTPT
VVSGTEDAAL TRTSTNRQRQ GKSSFKSFFR TMSLKVNSKT RNKDRKTKEE LAAEKALAEL
RNLPRNPLDL ELNELHVASN FNEVRKIIDD IFIDENHDAA SKAIRISTQN KSFSAMEKPY
SLTKIKSLQT EDDYSLPITS FIIETLEENS IHADLSHNDN AITSTDILIE EEEEMEQEEE
EEMLNYDDLD VISDKIDEVG AESSISTSND RGIIANATAN GPIIVGDSTE SVDTSNIENR
KLVVVNSTPD DHDYYATNDM NDNFITPNPS NESVETLAGV YKDFEVTNAT EANTEAGKTT
DINAETSNAI DAVADTENKV TAEDDATDTV NTGESMTDTT TSTTDNKNDK EVDKEVENAV
DSNVTTNDTI PDKAANIDNE SSSDNSIDAT TANTTNTNNF NDAEVNTEAT NTIVDNVTND
KFNSVDVSTT TPTATTVSGI PTADEMTNNV NTNRISTATV DSFTGKTGEN YESFITNAGK
DSNDNNADLK TPTNNSATTT TNTQSGVSNK KSNSKTGSSE QNPFQKKLMN YLNSLN
