ID   IRPA_SYNE7              Reviewed;         356 AA.
AC   P12608; Q31N77;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Iron-regulated protein A;
DE   Flags: Precursor;
GN   Name=irpA; OrderedLocusNames=Synpcc7942_1462;
OS   Synechococcus elongatus (strain PCC 7942 / FACHB-805) (Anacystis nidulans
OS   R2).
OC   Bacteria; Cyanobacteria; Synechococcales; Synechococcaceae; Synechococcus.
OX   NCBI_TaxID=1140;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3139627; DOI=10.1128/jb.170.10.4466-4476.1988;
RA   Reddy K.J., Bullerjahn G.S., Sherman D.M., Sherman L.A.;
RT   "Cloning, nucleotide sequence, and mutagenesis of a gene (irpA) involved in
RT   iron-deficient growth of the cyanobacterium Synechococcus sp. strain
RT   PCC7942.";
RL   J. Bacteriol. 170:4466-4476(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 7942 / FACHB-805;
RG   US DOE Joint Genome Institute;
RA   Copeland A., Lucas S., Lapidus A., Barry K., Detter J.C., Glavina T.,
RA   Hammon N., Israni S., Pitluck S., Schmutz J., Larimer F., Land M.,
RA   Kyrpides N., Lykidis A., Richardson P.;
RT   "Complete sequence of chromosome 1 of Synechococcus elongatus PCC 7942.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: IrpA occurs under iron-deficient growth conditions in
CC       cyanobacterium Synechococcus and disappears in cells recovering from
CC       iron starvation. It seems to be involved in iron acquisition, uptake or
CC       storage.
CC   -!- SUBUNIT: The iron-regulated protein A is one unit of the protein
CC       complex CPVI-4, which is synthesized under iron deficient conditions.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane.
CC   -!- INDUCTION: By iron deprivation.
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DR   EMBL; M22058; AAA27316.1; -; Genomic_DNA.
DR   EMBL; CP000100; ABB57492.1; -; Genomic_DNA.
DR   RefSeq; WP_011242408.1; NC_007604.1.
DR   AlphaFoldDB; P12608; -.
DR   SMR; P12608; -.
DR   STRING; 1140.Synpcc7942_1462; -.
DR   PRIDE; P12608; -.
DR   EnsemblBacteria; ABB57492; ABB57492; Synpcc7942_1462.
DR   KEGG; syf:Synpcc7942_1462; -.
DR   eggNOG; COG3487; Bacteria.
DR   HOGENOM; CLU_050043_0_0_3; -.
DR   OMA; QGFHTME; -.
DR   OrthoDB; 1385990at2; -.
DR   BioCyc; SYNEL:SYNPCC7942_1462-MON; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   CDD; cd14658; Imelysin-like_IrpA; 1.
DR   Gene3D; 1.20.1420.20; -; 1.
DR   InterPro; IPR018976; Imelysin-like.
DR   InterPro; IPR034982; Imelysin-like_IrpA.
DR   InterPro; IPR038352; Imelysin_sf.
DR   Pfam; PF09375; Peptidase_M75; 1.
PE   2: Evidence at transcript level;
KW   Cell inner membrane; Cell membrane; Iron; Membrane; Signal; Transmembrane.
FT   SIGNAL          1..44
FT   CHAIN           45..356
FT                   /note="Iron-regulated protein A"
FT                   /id="PRO_0000021525"
FT   REGION          75..145
FT                   /note="Hydrophilic"
FT   REGION          240..310
FT                   /note="Hydrophilic"
SQ   SEQUENCE   356 AA;  38614 MW;  EE96BF3D13F0372C CRC64;
     MIVTGSQVRQ GLNTWFVLPL RRTAIGLGCA GVATLFSACG QTQALITNQT IQGFVDQVVV
     PSYVSVAAGA TQLEQALQTY QQAPTAANLE AARQAWRVAR DRWEQTECFA FGPADSEGFD
     GAMDTWPIDR QGLKTAAAQP VEQREDSRKG FHAIEELLFA ATEPTLSDRQ HLVILATDLT
     KQAQGLVTRW QQASDQPAYR SVLLSAGSTD SAYPTLNAAG TEIVQGLVDS LSEVASEKIG
     GPLETQEPDR FESFVSRNTL SDLRNNWTGA WNVYRGQRSD GVAAGSLQQR LQQQHPVIAQ
     QLDQQFATAR QALWAIPEPI ETNLASPRGK VAVLTAQTAI AAVSDTLERQ VLPLVQ