IRS1_DROAN
ID IRS1_DROAN Reviewed; 940 AA.
AC B3MPN6;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 74.
DE RecName: Full=Insulin receptor substrate 1 {ECO:0000250|UniProtKB:Q9XTN2};
DE AltName: Full=Protein chico {ECO:0000250|UniProtKB:Q9XTN2};
GN Name=chico {ECO:0000250|UniProtKB:Q9XTN2}; ORFNames=GF14127;
OS Drosophila ananassae (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7217;
RN [1] {ECO:0000312|EMBL:EDV32284.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14024-0371.13 {ECO:0000312|EMBL:EDV32284.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Activates phosphatidylinositol 3-kinase when bound to the
CC regulatory p85 subunit. May mediate the control of various cellular
CC processes by insulin-like peptides. When phosphorylated by the insulin
CC receptor binds specifically to various cellular proteins containing SH2
CC domains. Involved in control of cell proliferation, cell size, and body
CC and organ growth throughout development. Also has a role in a signaling
CC pathway controlling the physiological response required to endure
CC periods of low nutrient conditions. Insulin/insulin-like growth factor
CC (IGF) signaling pathway has a role in regulating aging and is necessary
CC in the ovary for vitellogenic maturation (By similarity).
CC {ECO:0000250|UniProtKB:P35570, ECO:0000250|UniProtKB:Q9XTN2}.
CC -!- SUBUNIT: Bindings to phosphatidylinositol 3-kinase and SHP2.
CC {ECO:0000250|UniProtKB:Q9XTN2}.
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DR EMBL; CH902620; EDV32284.1; -; Genomic_DNA.
DR RefSeq; XP_001963063.1; XM_001963027.2.
DR AlphaFoldDB; B3MPN6; -.
DR SMR; B3MPN6; -.
DR STRING; 7217.FBpp0117319; -.
DR EnsemblMetazoa; FBtr0118827; FBpp0117319; FBgn0091154.
DR GeneID; 6496955; -.
DR KEGG; dan:6496955; -.
DR eggNOG; ENOG502QUNU; Eukaryota.
DR HOGENOM; CLU_012544_0_0_1; -.
DR InParanoid; B3MPN6; -.
DR OMA; HYRLNTR; -.
DR OrthoDB; 187805at2759; -.
DR PhylomeDB; B3MPN6; -.
DR ChiTaRS; chico; fly.
DR Proteomes; UP000007801; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0007568; P:aging; IEA:EnsemblMetazoa.
DR GO; GO:0009267; P:cellular response to starvation; IEA:EnsemblMetazoa.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0060250; P:germ-line stem-cell niche homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0042593; P:glucose homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0007295; P:growth of a germarium-derived egg chamber; IEA:EnsemblMetazoa.
DR GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0055088; P:lipid homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:EnsemblMetazoa.
DR GO; GO:0048133; P:male germ-line stem cell asymmetric division; IEA:EnsemblMetazoa.
DR GO; GO:0035264; P:multicellular organism growth; IEA:EnsemblMetazoa.
DR GO; GO:0061964; P:negative regulation of entry into reproductive diapause; IEA:EnsemblMetazoa.
DR GO; GO:0010897; P:negative regulation of triglyceride catabolic process; IEA:EnsemblMetazoa.
DR GO; GO:0008355; P:olfactory learning; IEA:EnsemblMetazoa.
DR GO; GO:1903688; P:positive regulation of border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa.
DR GO; GO:0050778; P:positive regulation of immune response; IEA:EnsemblMetazoa.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:EnsemblMetazoa.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:EnsemblMetazoa.
DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:EnsemblMetazoa.
DR GO; GO:0007285; P:primary spermatocyte growth; IEA:EnsemblMetazoa.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:EnsemblMetazoa.
DR GO; GO:0035159; P:regulation of tube length, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0034059; P:response to anoxia; IEA:EnsemblMetazoa.
DR GO; GO:0007296; P:vitellogenesis; ISS:UniProtKB.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; PTHR10614; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Differentiation; Growth regulation; Oogenesis; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..940
FT /note="Insulin receptor substrate 1"
FT /id="PRO_0000395319"
FT DOMAIN 8..109
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 122..236
FT /note="IRS-type PTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
FT REGION 523..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 895..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 407..410
FT /note="YXXM motif 1"
FT /evidence="ECO:0000255"
FT MOTIF 639..642
FT /note="YXXM motif 2"
FT /evidence="ECO:0000255"
FT MOD_RES 284
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 285
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 407
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
FT MOD_RES 548
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 883
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
FT MOD_RES 904
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 907
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 920
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
SQ SEQUENCE 940 AA; 105564 MW; 13B63E9DE47973CE CRC64;
MASISDDGMV LSGYHKKLKT MKKKFFVLYE ETSINQARLE YYDTEKKFLQ RAEPKRVIYL
KDCFNINRRL DTKHRFVIVL SSREGGFGIV LESENDLRKW LDKLLLLQRN IANVNGQVYS
AYEHVWQVII QKKGMSEKVG ITGTYHCCLS AKSLTFVCIG PEKTANGDDR ISSIEILLTT
IRRCGHASPQ CIFYMELGRQ SVLGSGELWM ETDNAAIATN MHNTILSAMS AKTDSNTNLI
NVYQARPDIS HEPMRKRSSS ANEASKPINV IQNRQNSLEL RNCSSPHNYG FPRERCDSLP
TRNGTLSESS NQSYFGSNLG LRSNTISGIR PHSTSKHSNS PTFNMPLRCS ESEDSSISID
ESDDNASFGH YRLNTRSSKG AIPEENLDDF ASAEYCKGSG PSGDDNYIPM TPIKPASFCE
PDKVELPKPD DPNLHINFPE HTSEKLENDF DLDSDNQCGR PIRAYSIGNK VEHLKLNRRL
GYLNDTGQNS NRVRAYSVGS KSKIPRCDLQ RVVLVEDNRF DTNRSQNNIS KEGPISGTST
NREKKSTSAP LLSLKNQINQ DRMSDLMEID FSQSSKIEPW TPAQFKRNVM DVVPKNIESV
FPKSYRNDSS NLTLHATSQK DIFNGGKLNT TESSSEGGYL EMKPVGNAFS SSPVTLPSKI
EKLKLKDNTE LPVHELHKVS SYNIPPEKRK EQTPTQTRIE EKTLNSQLNE KLINTESANV
VANITPNVPE LKSDKKNNVE SLIIENNNWD LGTTDEKKLV HSISSEDYTQ IKDKLNDLTK
NNEVGYKILQ IKSDSSLISS KITLKNRLRD NLERQQRLTE SVNTIPDKSP SATTKGTFYS
LGNNFQTPPN NVVNNTLDNI LQTKDLNFPS RPSSQASQPE LHYAKLDLPN CSDQNPAKYL
KRGSRESPPV ATCAEDGNTY ARIDFDQSDS SSSSSKIFNM
