IRS1_DROER
ID IRS1_DROER Reviewed; 948 AA.
AC B3N946;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Insulin receptor substrate 1 {ECO:0000250|UniProtKB:Q9XTN2};
DE AltName: Full=Protein chico {ECO:0000250|UniProtKB:Q9XTN2};
GN Name=chico {ECO:0000250|UniProtKB:Q9XTN2}; ORFNames=GG23965;
OS Drosophila erecta (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7220;
RN [1] {ECO:0000312|EMBL:EDV58481.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tucson 14021-0224.01 {ECO:0000312|EMBL:EDV58481.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Activates phosphatidylinositol 3-kinase when bound to the
CC regulatory p85 subunit. May mediate the control of various cellular
CC processes by insulin-like peptides. When phosphorylated by the insulin
CC receptor binds specifically to various cellular proteins containing SH2
CC domains. Involved in control of cell proliferation, cell size, and body
CC and organ growth throughout development. Also has a role in a signaling
CC pathway controlling the physiological response required to endure
CC periods of low nutrient conditions. Insulin/insulin-like growth factor
CC (IGF) signaling pathway has a role in regulating aging and is necessary
CC in the ovary for vitellogenic maturation (By similarity).
CC {ECO:0000250|UniProtKB:P35570, ECO:0000250|UniProtKB:Q9XTN2}.
CC -!- SUBUNIT: Bindings to phosphatidylinositol 3-kinase and SHP2.
CC {ECO:0000250|UniProtKB:Q9XTN2}.
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DR EMBL; CH954177; EDV58481.1; -; Genomic_DNA.
DR RefSeq; XP_001969422.1; XM_001969386.2.
DR RefSeq; XP_015014986.1; XM_015159500.1.
DR AlphaFoldDB; B3N946; -.
DR SMR; B3N946; -.
DR STRING; 7220.FBpp0142511; -.
DR EnsemblMetazoa; FBtr0144019; FBpp0142511; FBgn0116104.
DR EnsemblMetazoa; FBtr0406929; FBpp0365490; FBgn0116104.
DR GeneID; 6542588; -.
DR KEGG; der:6542588; -.
DR eggNOG; ENOG502QUNU; Eukaryota.
DR HOGENOM; CLU_012544_0_0_1; -.
DR OMA; HYRLNTR; -.
DR OrthoDB; 187805at2759; -.
DR PhylomeDB; B3N946; -.
DR ChiTaRS; chico; fly.
DR Proteomes; UP000008711; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0007568; P:aging; IEA:EnsemblMetazoa.
DR GO; GO:0009267; P:cellular response to starvation; IEA:EnsemblMetazoa.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0060250; P:germ-line stem-cell niche homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0042593; P:glucose homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0007295; P:growth of a germarium-derived egg chamber; IEA:EnsemblMetazoa.
DR GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0055088; P:lipid homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:EnsemblMetazoa.
DR GO; GO:0048133; P:male germ-line stem cell asymmetric division; IEA:EnsemblMetazoa.
DR GO; GO:0035264; P:multicellular organism growth; IEA:EnsemblMetazoa.
DR GO; GO:0061964; P:negative regulation of entry into reproductive diapause; IEA:EnsemblMetazoa.
DR GO; GO:0010897; P:negative regulation of triglyceride catabolic process; IEA:EnsemblMetazoa.
DR GO; GO:0008355; P:olfactory learning; IEA:EnsemblMetazoa.
DR GO; GO:1903688; P:positive regulation of border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa.
DR GO; GO:0050778; P:positive regulation of immune response; IEA:EnsemblMetazoa.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:EnsemblMetazoa.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:EnsemblMetazoa.
DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:EnsemblMetazoa.
DR GO; GO:0007285; P:primary spermatocyte growth; IEA:EnsemblMetazoa.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:EnsemblMetazoa.
DR GO; GO:0035159; P:regulation of tube length, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0034059; P:response to anoxia; IEA:EnsemblMetazoa.
DR GO; GO:0007296; P:vitellogenesis; ISS:UniProtKB.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; PTHR10614; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Differentiation; Growth regulation; Oogenesis; Phosphoprotein; Repeat.
FT CHAIN 1..948
FT /note="Insulin receptor substrate 1"
FT /id="PRO_0000395320"
FT DOMAIN 8..109
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 122..236
FT /note="IRS-type PTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
FT REGION 247..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 528..559
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 703..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..948
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 410..413
FT /note="YXXM motif 1"
FT /evidence="ECO:0000255"
FT MOTIF 640..643
FT /note="YXXM motif 2"
FT /evidence="ECO:0000255"
FT COMPBIAS 704..721
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 931..948
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 286
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 342
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 410
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
FT MOD_RES 554
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 891
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
FT MOD_RES 912
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 915
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 928
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
SQ SEQUENCE 948 AA; 105969 MW; 2474C62591F7FC08 CRC64;
MASISDDGMA LSGYLKKLKT MKKKFFVLYE ETSNSSARLE YYDTEKKFLQ RAEPKRVIYL
KNCFNINRRL DTKQRFVIVL SSRDGGFGIV LESENDLRKW LDKLLVLQRN IANTNGTAYS
PYDQVWQVVI QKKGISEKVG ITGTYHCCLT SKSLTFVCIG PDKTPNGEER VASIEILLTT
IRRCGHASPQ CIFYVELGRQ SVLGSGDLWM ETDNAAVATN MHNTILSAMS AKTESNTNLI
NVYQNRPDLS HEPMRKRSSS ANEASKPINV NVIQNSQNSL DLRSCSSPHN YGFGRERCDS
LPTRNGTLSE SSNQTYFGSN HGLRSNTISG IRPHSSNKHS NSPTFTMPLR CSASEESSIS
IEESDDNGSF SHYRLNTRSS ETAIPEENID DFASAEFSKV SEQNESDENY IPMTPINPTD
AIHEKEKVDM QRLEDGSLHF DFPEHASEKL ARDFDLDSDN QCGRPIRAYS IGNKVEHLKF
NKRLGHLNDT GQNPNRVRAY SVGSKSKIPR CDLQRVVLVE DNKHEFAANR SQSSITKEGT
SYSTSSNRQK KSTSAPLLSL KNHINSDRMS DLMEIDFSQA TNLEKQKFIK NNEIPKYIEN
VFPKTPRTDS SSLTLHATSQ KDIFNGTKLN NTVNASEEGY LEMKPVGNAY TPSSNCLPIK
VEKLKISDYT APLTTAAPVH DLNKISAYNI SAEKWKEQSL CEEKKSNSPL NETPCSLKPT
DVESNSHDEH STNNMECEVS VQCDKQNNLD DKVAENNNLD IGGHEEKKLV HSISSEDYTQ
IKDKSNDFTK FNEAGYKILQ IKSDSSLISL KLYQKGIHKD NLERSHRLTE SVNTIPDNAT
ASSSVTKFNI NTKAADSRST DPSTPQNILQ IKDLNFPSRS SSRISQPELH YASLDLPHCS
GQNPAKYLKR GSRESPPVSA CPGDGNTYAK IDFDQSDSSS SSSNIFNT
