IRS1_DROSE
ID IRS1_DROSE Reviewed; 964 AA.
AC B4HWI2;
DT 13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Insulin receptor substrate 1 {ECO:0000250|UniProtKB:Q9XTN2};
DE AltName: Full=Protein chico {ECO:0000250|UniProtKB:Q9XTN2};
GN Name=chico {ECO:0000250|UniProtKB:Q9XTN2}; ORFNames=GM11923;
OS Drosophila sechellia (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7238;
RN [1] {ECO:0000312|EMBL:EDW52377.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Rob3c / Tucson 14021-0248.25 {ECO:0000312|EMBL:EDW52377.1};
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Activates phosphatidylinositol 3-kinase when bound to the
CC regulatory p85 subunit. May mediate the control of various cellular
CC processes by insulin-like peptides. When phosphorylated by the insulin
CC receptor binds specifically to various cellular proteins containing SH2
CC domains. Involved in control of cell proliferation, cell size, and body
CC and organ growth throughout development. Also has a role in a signaling
CC pathway controlling the physiological response required to endure
CC periods of low nutrient conditions. Insulin/insulin-like growth factor
CC (IGF) signaling pathway has a role in regulating aging and is necessary
CC in the ovary for vitellogenic maturation (By similarity).
CC {ECO:0000250|UniProtKB:P35570, ECO:0000250|UniProtKB:Q9XTN2}.
CC -!- SUBUNIT: Bindings to phosphatidylinositol 3-kinase and SHP2.
CC {ECO:0000250|UniProtKB:Q9XTN2}.
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DR EMBL; CH480818; EDW52377.1; -; Genomic_DNA.
DR RefSeq; XP_002036454.1; XM_002036418.1.
DR AlphaFoldDB; B4HWI2; -.
DR SMR; B4HWI2; -.
DR STRING; 7238.B4HWI2; -.
DR EnsemblMetazoa; FBtr0194908; FBpp0193400; FBgn0166864.
DR GeneID; 6611937; -.
DR KEGG; dse:6611937; -.
DR HOGENOM; CLU_012544_0_0_1; -.
DR OMA; HYRLNTR; -.
DR PhylomeDB; B4HWI2; -.
DR ChiTaRS; chico; fly.
DR Proteomes; UP000001292; Unassembled WGS sequence.
DR GO; GO:0005938; C:cell cortex; IEA:EnsemblMetazoa.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:EnsemblMetazoa.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0007568; P:aging; IEA:EnsemblMetazoa.
DR GO; GO:0009267; P:cellular response to starvation; IEA:EnsemblMetazoa.
DR GO; GO:0008340; P:determination of adult lifespan; IEA:EnsemblMetazoa.
DR GO; GO:0060250; P:germ-line stem-cell niche homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0042593; P:glucose homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0007295; P:growth of a germarium-derived egg chamber; IEA:EnsemblMetazoa.
DR GO; GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0055088; P:lipid homeostasis; IEA:EnsemblMetazoa.
DR GO; GO:0060291; P:long-term synaptic potentiation; IEA:EnsemblMetazoa.
DR GO; GO:0048133; P:male germ-line stem cell asymmetric division; IEA:EnsemblMetazoa.
DR GO; GO:0035264; P:multicellular organism growth; IEA:EnsemblMetazoa.
DR GO; GO:0061964; P:negative regulation of entry into reproductive diapause; IEA:EnsemblMetazoa.
DR GO; GO:0010897; P:negative regulation of triglyceride catabolic process; IEA:EnsemblMetazoa.
DR GO; GO:0008355; P:olfactory learning; IEA:EnsemblMetazoa.
DR GO; GO:1903688; P:positive regulation of border follicle cell migration; IEA:EnsemblMetazoa.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:EnsemblMetazoa.
DR GO; GO:0045793; P:positive regulation of cell size; IEA:EnsemblMetazoa.
DR GO; GO:0050778; P:positive regulation of immune response; IEA:EnsemblMetazoa.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:EnsemblMetazoa.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:EnsemblMetazoa.
DR GO; GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase signaling; IEA:EnsemblMetazoa.
DR GO; GO:0007285; P:primary spermatocyte growth; IEA:EnsemblMetazoa.
DR GO; GO:0043491; P:protein kinase B signaling; IEA:EnsemblMetazoa.
DR GO; GO:0035159; P:regulation of tube length, open tracheal system; IEA:EnsemblMetazoa.
DR GO; GO:0034059; P:response to anoxia; IEA:EnsemblMetazoa.
DR GO; GO:0007296; P:vitellogenesis; ISS:UniProtKB.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; PTHR10614; 1.
DR Pfam; PF02174; IRS; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Differentiation; Growth regulation; Oogenesis; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..964
FT /note="Insulin receptor substrate 1"
FT /id="PRO_0000395321"
FT DOMAIN 8..109
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 122..236
FT /note="IRS-type PTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
FT REGION 249..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 527..560
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 698..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 921..964
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 410..413
FT /note="YXXM motif 1"
FT /evidence="ECO:0000255"
FT MOTIF 640..643
FT /note="YXXM motif 2"
FT /evidence="ECO:0000255"
FT COMPBIAS 528..560
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..728
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 947..964
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 286
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 287
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 342
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 410
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
FT MOD_RES 554
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 907
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
FT MOD_RES 928
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 931
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9XTN2"
FT MOD_RES 944
FT /note="Phosphotyrosine; by INSR"
FT /evidence="ECO:0000250|UniProtKB:P35570"
SQ SEQUENCE 964 AA; 107560 MW; 20F16488639617CF CRC64;
MASISDDGMA LSGNLKKLKT MKKKFFVLYE ETSTSSARLE YYDTEKKFLQ RAEPKRVIYL
KNCFNINRRL DTKHRFVIVL SSRDGGFGIV LENENDLRKW LDKLLVLQRN IANSNGTAHS
PYDQVWQVVI QKKGISEKVG ITGTYHCCLT SKSLTFVCIG PEKTPNGEDR VASIEILLTT
IRRCGHASPQ CIFYVELGRQ SVLGSGDLWM ETDNAAVATN MHNMILSAMS AKTESNTNLI
NVYQNRPDLS HEPMRKRSSS ANEASKPINV NVIQNSQNSL ELRSCSSPHN YGFSRERCDS
LPTRNGTLSE SSNQTYFGSN HGLRFNTISG IRPHSTNKHS NSPTFTMPLR CSESEDSSIS
VDESDDNGSF SHYRLNTRTS ETAIPEENID DFASAEFSKV TEPNESDENY IPMNPVNPTD
AIHEKEKADL QRLEDASLHF NFPEHASEKL AKDFDLDSDN QCCRPIRAYS IGNKVEHLKF
NKRLGHLNDT GQNPNRVRAY SVGSKSKIPR CDLQRVVLVE DNKHEFASNR SQSSIGKEGS
SYGSSANRQK KSTSAPLLSL KNQINSDRMS DLMEIDFSQA TNLEKQKFIK NNEIPKYIEN
VFPKAPRTDS SSLTLHATSQ KDIFNGSKLN NTAITSEDGY LEMKPVGNGY TPSSNCLPIK
VEKLKLSDYQ TTAPPLLTAT AAPVQDLNKI STYNISAEKW REQPSRSEEK KSNSPLNDNP
FSLKPTNVES KSKSHDVHSA NQIDCEKVCV QSDKLNNLTD KIVENNNLDI GGHEEKKLVH
SISSEDYTQI KDKANDFTKF NEAGYKILQI KSDSSLISSK LYQKGMHKDN LERTHRLTES
VNTIPDNATA TVGSSSLTKF NINSVKPAAD SRSTGTDPST AQNILQIKDL NFPSRSSSRI
SQPELHYASL DLPHCSGQNP AKYLKRGSRE SPPVSACPED GNTYARIDFD QSDSSSSSSN
IFNT
