ID   IRS1_HCMVM              Reviewed;         847 AA.
AC   Q6SW04; D2K3U7;
DT   13-JUN-2012, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Protein IRS1;
GN   Name=IRS1;
OS   Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Herpesviridae; Betaherpesvirinae; Cytomegalovirus.
OX   NCBI_TaxID=295027;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15105547; DOI=10.1099/vir.0.79888-0;
RA   Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
RA   Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
RA   Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G., Davison A.J.;
RT   "Genetic content of wild-type human cytomegalovirus.";
RL   J. Gen. Virol. 85:1301-1312(2004).
CC   -!- FUNCTION: Acts as a transactivator along with IE2, and is required for
CC       oriLyt-dependent DNA replication in the transient transfection
CC       replication assay using native promoters.
CC   -!- SUBUNIT: Interacts (via N-terminus) with the viral DNA polymerase
CC       accessory subunit UL44. Interacts (via C-terminus) with host EIF2AK2.
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Host nucleus {ECO:0000250}. Note=Isoform IRS1-263 is
CC       predominantly nuclear. {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative initiation; Named isoforms=2;
CC       Name=IRS1;
CC         IsoId=Q6SW04-1; Sequence=Displayed;
CC       Name=IRS1-263;
CC         IsoId=Q6SW04-2; Sequence=VSP_043921;
CC   -!- SIMILARITY: Belongs to the herpesviridae US22 family. {ECO:0000305}.
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DR   EMBL; AY446894; AAR31691.1; -; Genomic_DNA.
DR   RefSeq; YP_081587.1; NC_006273.2.
DR   BioGRID; 1678127; 1.
DR   PRIDE; Q6SW04; -.
DR   GeneID; 3077574; -.
DR   KEGG; vg:3077574; -.
DR   Reactome; R-HSA-9609690; HCMV Early Events.
DR   Reactome; R-HSA-9610379; HCMV Late Events.
DR   Proteomes; UP000000938; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0019033; C:viral tegument; TAS:Reactome.
DR   GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0039580; P:suppression by virus of host PKR signaling; IEA:UniProtKB-KW.
DR   GO; GO:0039502; P:suppression by virus of host type I interferon-mediated signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR003360; US22-like.
DR   Pfam; PF02393; US22; 2.
PE   3: Inferred from homology;
KW   Alternative initiation; Host cytoplasm; Host nucleus;
KW   Host-virus interaction; Inhibition of host innate immune response by virus;
KW   Inhibition of host interferon signaling pathway by virus;
KW   Inhibition of host PKR by virus; Reference proteome; Transcription;
KW   Viral immunoevasion; Virion.
FT   CHAIN           1..847
FT                   /note="Protein IRS1"
FT                   /id="PRO_0000417831"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          607..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          715..847
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        26..49
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..622
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        734..751
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        752..767
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..584
FT                   /note="Missing (in isoform IRS1-263)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_043921"
SQ   SEQUENCE   847 AA;  91190 MW;  2B699C571D00C980 CRC64;
     MAQRNGMSPR PPPLGRGRGA GGPSGVGSSP PSSCVPMGAT STAGTGASAA PTATPGHGVH
     RVEPRGPPGA PPSSGNNSNF WHGPERLLLS QIPVERQALT ELEYQAMGAV WRAAFLANST
     GRAMRKWSQR DAGTLLPLGR PYGFYARVTP RSQMNGVGAT DLRQLSPRDA WIVLVATVVH
     EVDPAADPTV GDKAGHPEGL CAQDGLYLAL GAGFRVFVYD LANNTLILAA RDADEWFRHG
     AGEVVRLYRC NRLGVGTPRA TLLPQPALRQ TLLRAEEATA LGRELRRRWA GTTVALQTPG
     RRLQPMVLLG AWQELAQYEP FASAPHPASL LTAVRRHLNQ RLCCGWLALG AVLPARWLGC
     AAGPATGTTS PPAASGTETE AAGGDAPCAM AGAVGSAVTI PPQPYGGAGG SAICVPNADA
     HAVVGADATA AAAAAAAAPT VMVGPTAMAG PAASGTVPRA MLVVVLDELG AVFGYCPLDG
     HVYPLAAELS HFLRAGVLGA LALGRESAPA AEAARRLLPE LDREQWERPR WDALHLHPRA
     ALWAREPHGQ WEFMFREQRG DPIHDPVAFR LSDARTLGLD LTTVMTERQS QLPEKYIGFY
     QIRKPPWLME QPPPPSRQTK PDAATMPPPL SAQASVSYAL RYDDESWRPL STVDDHKAWL
     DLDESHWVLG DSRPDDIKQR RLLKATQRRG AEIDRPMPVV PEECYDQRFT TEGHQVIPLC
     ASEPEDDDED PTYDELPSRP PQKHKPPDKP PRLCKTGPGP PPLPPKQRHG STDGKVSAPR
     QSEHHKRQTR PPRPPPPKFG DRTAAHLSQN MRDMYLDMCT SSGHRPRPPA PPRPKKCQTH
     APHHVHH