IRS2A_XENLA
ID IRS2A_XENLA Reviewed; 1074 AA.
AC Q9DF49; Q6GQH6;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Insulin receptor substrate 2-A;
DE Short=IRS-2-A;
DE AltName: Full=Insulin receptor substrate-undetermined designation;
DE AltName: Full=Insulin receptor substrate-unique;
DE Short=xIRS-u;
GN Name=irs2-a; Synonyms=irsu;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000312|EMBL:AAH72768.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH72768.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAG18441.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-1071, AND FUNCTION.
RC TISSUE=Ovary {ECO:0000269|PubMed:9717835};
RX PubMed=9717835; DOI=10.1210/mend.12.8.0147;
RA Ohan N., Bayaa M., Kumar P., Zhu L., Liu X.J.;
RT "A novel insulin receptor substrate protein, xIRS-u, potentiates insulin
RT signaling: functional importance of its pleckstrin homology domain.";
RL Mol. Endocrinol. 12:1086-1098(1998).
CC -!- FUNCTION: Potentiates insulin signaling. {ECO:0000269|PubMed:9717835}.
CC -!- PTM: Phosphorylated by INSR. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG18441.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; BC072768; AAH72768.1; -; mRNA.
DR EMBL; AF297960; AAG18441.1; ALT_FRAME; mRNA.
DR RefSeq; NP_001084242.1; NM_001090773.1.
DR AlphaFoldDB; Q9DF49; -.
DR SMR; Q9DF49; -.
DR DNASU; 399388; -.
DR GeneID; 399388; -.
DR KEGG; xla:399388; -.
DR CTD; 399388; -.
DR Xenbase; XB-GENE-865320; irs4.S.
DR OrthoDB; 298675at2759; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 399388; Expressed in testis and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005158; F:insulin receptor binding; ISS:UniProtKB.
DR GO; GO:0005159; F:insulin-like growth factor receptor binding; ISS:UniProtKB.
DR GO; GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:UniProtKB.
DR CDD; cd01204; PTB_IRS; 1.
DR Gene3D; 2.30.29.30; -; 2.
DR InterPro; IPR039011; IRS.
DR InterPro; IPR002404; IRS_PTB.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR10614; PTHR10614; 1.
DR Pfam; PF02174; IRS; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00628; INSULINRSI.
DR SMART; SM00233; PH; 1.
DR SMART; SM00310; PTBI; 1.
DR PROSITE; PS51064; IRS_PTB; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 2: Evidence at transcript level;
KW Phosphoprotein; Reference proteome; Repeat; Transducer.
FT CHAIN 1..1074
FT /note="Insulin receptor substrate 2-A"
FT /id="PRO_0000076225"
FT DOMAIN 63..168
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 193..297
FT /note="IRS-type PTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 426..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 33..36
FT /note="YXXM motif 1"
FT /evidence="ECO:0000255"
FT MOTIF 145..148
FT /note="YXXM motif 2"
FT /evidence="ECO:0000255"
FT MOTIF 496..499
FT /note="YXXM motif 3"
FT /evidence="ECO:0000255"
FT MOTIF 592..595
FT /note="YXXM motif 4"
FT /evidence="ECO:0000255"
FT MOTIF 605..608
FT /note="YXXM motif 5"
FT /evidence="ECO:0000255"
FT MOTIF 631..634
FT /note="YXXM motif 6"
FT /evidence="ECO:0000255"
FT MOTIF 663..666
FT /note="YXXM motif 7"
FT /evidence="ECO:0000255"
FT MOTIF 710..713
FT /note="YXXM motif 8"
FT /evidence="ECO:0000255"
FT MOTIF 888..891
FT /note="YXXM motif 9"
FT /evidence="ECO:0000255"
FT COMPBIAS 343..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..458
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 476..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 398
FT /note="A -> P (in Ref. 2; AAG18441)"
FT /evidence="ECO:0000305"
FT CONFLICT 475
FT /note="S -> I (in Ref. 2; AAG18441)"
FT /evidence="ECO:0000305"
FT CONFLICT 785
FT /note="S -> N (in Ref. 2; AAG18441)"
FT /evidence="ECO:0000305"
FT CONFLICT 1027
FT /note="S -> Y (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 1047
FT /note="S -> I (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 1052..1053
FT /note="SG -> NW (in Ref. 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 1062..1064
FT /note="RCD -> SVN (in Ref. 2)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1074 AA; 117910 MW; 9262B6ECB6E7BF2C CRC64;
MAGVLCPTEE DRSSRAALRM LPPQPCPDES GAYRRMSGPT LSQVQEEPAA EPPQPPASAA
EDDVRKRGYL RKQKHGHKRY FVLRSQSHLG PARLEYYDNE KKFRSGQRSG CHPKRVIPLY
LCFTVSRRAD AKNKHLVALY TKDEYFAMAA ENEQEQDGWY QALSELINES KGACLDTEEL
EENYGTLRPG TVFKEVWQVN VKPRGLGQAK NLSGVYRLCL SSKAVHLVKL NSDVACVHLL
LMNIRRCGHS ENYFFIEVGR SSSTGAGELW MQVDDCVVAQ HMHETFLDTM KALKAYSEFR
PRSKSQSSCT NPISFITTRR YLGNLPPSQT GLQRRARTES MVGTPPSAKN NSFRFRTSSE
GEGTMTRPFR SVTGSLSHLN TARINLGKQE GAGRYVRAPF NSGYQSRSAS LPVSHFPSAT
SPISVCSSSG HGSASETLTR PSSSSVCGSP SDGGFISSDE YGSSPGDLRY FRVRSNTPDS
LGNTPPIQEE NTLSDYMSMS THSQPDSRDD YMEADKCFRK RTYSLTKHTN SASKQKSQTA
ISLGEDSEEI NKQFAFAESP KLKDSSLVDD YSNGVIDSVC NQSRSKASDD GYMPMMPSNL
YDSDYLPMAP KTVSAPKQIN RCPSQADSKG YMMMFPINSS PVKNVFGGAA TKSNLEKLSN
GGYMDMSYGN STKQIHDSNL NNNSRGLSSY FSLPRSFKSL TKQTTDQNEY VPMSSPGKLL
HLGAENGVDV CKDGAVHDIA KIELKSSSSI LDQQVKRPNK LTLGIRGSNT IPRMFDHSAP
AEPTSPGEYI NIDFSDKASS TPYSLSADGS PSSLGSSCDH RQSPLSDYMS VDIDVQSPKA
TAEQSNSLTD ISLYACTVVS RMQPNAEYAK LPCGTACVSK TDNIMDDYTT MTFNMAMTPP
RSFASETENG TKVDSPSSIV NRLCIGELTS LNSGFSLPNP LPEPIAGPKV IRADSQGRRR
HSSETFASSS TVTTSSSCFT ESGKRHSSAS FDNVWLKPDE NSCEQENKMS RHCSTGFQNG
LNYISLSMHN GVCEPTSPDC HQHQNGSRNL ESGGYVSIDF TRCDCLKCPT SRKD
