ID   IRS2B_XENLA             Reviewed;        1077 AA.
AC   Q5RJW5;
DT   10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Insulin receptor substrate 2-B;
DE            Short=IRS-2-B;
GN   Name=irs2-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Spleen;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Potentiates insulin signaling. {ECO:0000250}.
CC   -!- PTM: Phosphorylated by INSR. {ECO:0000250}.
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DR   EMBL; BC086477; AAH86477.1; -; mRNA.
DR   RefSeq; NP_001088662.1; NM_001095193.1.
DR   AlphaFoldDB; Q5RJW5; -.
DR   SMR; Q5RJW5; -.
DR   BioGRID; 105916; 1.
DR   IntAct; Q5RJW5; 1.
DR   DNASU; 495836; -.
DR   GeneID; 495836; -.
DR   KEGG; xla:495836; -.
DR   CTD; 495836; -.
DR   Xenbase; XB-GENE-6253207; irs4.L.
DR   OMA; DDVRKCG; -.
DR   OrthoDB; 298675at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 495836; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005158; F:insulin receptor binding; IEA:InterPro.
DR   GO; GO:0008286; P:insulin receptor signaling pathway; IEA:InterPro.
DR   CDD; cd01204; PTB_IRS; 1.
DR   Gene3D; 2.30.29.30; -; 2.
DR   InterPro; IPR039011; IRS.
DR   InterPro; IPR002404; IRS_PTB.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   PANTHER; PTHR10614; PTHR10614; 1.
DR   Pfam; PF02174; IRS; 1.
DR   Pfam; PF00169; PH; 1.
DR   PRINTS; PR00628; INSULINRSI.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00310; PTBI; 1.
DR   PROSITE; PS51064; IRS_PTB; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   2: Evidence at transcript level;
KW   Phosphoprotein; Reference proteome; Repeat; Transducer.
FT   CHAIN           1..1077
FT                   /note="Insulin receptor substrate 2-B"
FT                   /id="PRO_0000076226"
FT   DOMAIN          65..170
FT                   /note="PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT   DOMAIN          195..299
FT                   /note="IRS-type PTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00389"
FT   REGION          1..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          342..373
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          428..464
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          476..495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          530..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           33..36
FT                   /note="YXXM motif 1"
FT   MOTIF           147..150
FT                   /note="YXXM motif 2"
FT   MOTIF           499..502
FT                   /note="YXXM motif 3"
FT   MOTIF           595..598
FT                   /note="YXXM motif 4"
FT   MOTIF           608..611
FT                   /note="YXXM motif 5"
FT   MOTIF           634..637
FT                   /note="YXXM motif 6"
FT   MOTIF           666..669
FT                   /note="YXXM motif 7"
FT   MOTIF           713..716
FT                   /note="YXXM motif 8"
FT   MOTIF           891..894
FT                   /note="YXXM motif 9"
FT   COMPBIAS        428..461
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..495
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        530..544
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1077 AA;  117922 MW;  085EF236B2911F4B CRC64;
     MAGVLCPTEE DRSIRAAVRM LPPQPCPDES GGYRRMSGPT LSQVQEEPAA ETPQPPAPAS
     TAEDDVRKRG YLRKQKHGHK RYFVLRSQSH LGPARLEYYD NEKKFRSGQR SGCHPKRVIP
     LYLCFTVSRR ADAKNKHLVA LYTKDEYFAM AAENEQEQDG WYQALSELIN ESKGACLDTE
     ELEENYGTLR PGTVFKEVWQ VNVKPRGLGQ AKNLSGVYRL CLSSKAVHLV KLNSDVACVH
     LLLMNIRRCG HSENYFFIEV GRSSSTGAGE LWMQVDDCVV AQHMHETFLD TMKALKAYSE
     FRPRSKSQSS GTNPISFITT RRYLGNLPPS QTGLQQRRAR TETVVGTPPS AKNNSFRFRT
     SSEGEGTMTR PFRSVTGSLS HLNTARINLG KQEGVGRYVR APFNSGYHSR SASLPVSHFP
     SATSPISVCS SNGHGSASET LTRPSSSSVC GSPSDGGFIS SDEYGSSPGD LRYFRVRSNT
     PDSLGNTPPI QEENTLSDYM SMSAHSQPDS RDDYMEADKC FRKRTYSLTK PTNAASQQKS
     QTAVSLDEDS EETNKQFAYA ESPKLKDSSH VEDYSNGVID SVCNHSRRKA SDDGYMPMMP
     SNSYDSDYLP MAPKSVSAPK QINSCPSQVD SKGYMMMFPV NGSPVKNVFG GAATKSNIEK
     LSNGGYMDMS YGNSIKQVHD SSLNNNSRGL SSYFSLPRSF KSLTKQTSDH SEYVPMSSPG
     KLLHLGAENG VDACTNGADH NVAKTELKSP SSTLDQQVKR PTKLMLGIRG SNTIPRMFDH
     SASAEPTSPG EYINIDFSDK ASSTPCSLSA EGSPSSLGSS CDHRHSPLSD YMSVDIDVQS
     PKATADLCDS LTDISPYACT VVSRMQPNAE YAKLPCGTAC VSKTDNRIDD YTTMTFNMAM
     TPPRSFAGET ENGTKVDSPS SIVNRLCIGD LTSLNGGFSL PNPLPEPMAG PKVIRADSQG
     RRRHSSETFS SASTVTTSSS CFTESSKRHS SASFDNVWLK SDENCCEQEN KMSRNCSTGF
     QNGLNYIALS MHDGVCEPTS PACHQHQNGS RILENGGYVS IDFTRSDCLK CPSSRKD