ID   IRS4_ASPCL              Reviewed;         501 AA.
AC   A1CBF3;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 66.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=irs4; ORFNames=ACLA_015090;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; DS027049; EAW13071.1; -; Genomic_DNA.
DR   RefSeq; XP_001274497.1; XM_001274496.1.
DR   AlphaFoldDB; A1CBF3; -.
DR   SMR; A1CBF3; -.
DR   STRING; 5057.CADACLAP00000760; -.
DR   EnsemblFungi; EAW13071; EAW13071; ACLA_015090.
DR   GeneID; 4706932; -.
DR   KEGG; act:ACLA_015090; -.
DR   VEuPathDB; FungiDB:ACLA_015090; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_014603_1_0_1; -.
DR   OMA; RKRWQSE; -.
DR   OrthoDB; 1175008at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..501
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308748"
FT   DOMAIN          402..491
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   REGION          1..270
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          286..375
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          396..415
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..38
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        43..59
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..130
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..200
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..270
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        350..365
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        396..411
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   501 AA;  54359 MW;  98EFE1F2645A5620 CRC64;
     MAVHPEDKCA ELPEPGSVRD KIGMFTAHSD DKRSLQPPSG RERGSVAAST SRSPQPAAGP
     GTTQRPPVPK KKPSLLADMG ARPGFNQPRS QESCDSGTTD VLARKPVRSM TAGNGMPEGP
     QQTNKEMTIR SASIPARKPV PAPPSFGPPN TAQVPITRVR PSPPPPRKGG ATPVSKITSL
     GEVKTGEISR SSQASANSKN GPAVGAEPRP KLPPRPEALS TSQSPLKSHR ILLNEHDIRK
     GSMSPSSAST YSPLQQNGSS SSLLDQSSGL DEEALSNAIV ASSLASAKAL STKKVPPPPP
     PQRQPRSRSI LPLHSTKYDS PNDSSPTPSL RTTLRTPTKA DEDQHDHHRH RKHIIPKHPH
     KHHEGDRKRW QSEVTEKERK RYEGVWAANK GYLIPISNPG NASSKQEDPR SAYPPSASEM
     VLNIVVRDIW SRSRLPAPIL SQIWDLVDRQ KIGLLTREEF VVGMWLIDQQ LKGHKLPTKV
     PNSVWDSVRG VSGIKLPKFP V