ID   IRS4_ASPFU              Reviewed;         513 AA.
AC   Q4WVH0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=irs4; ORFNames=AFUA_5G12070;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; AAHF01000003; EAL91406.1; -; Genomic_DNA.
DR   RefSeq; XP_753444.1; XM_748351.1.
DR   AlphaFoldDB; Q4WVH0; -.
DR   SMR; Q4WVH0; -.
DR   STRING; 746128.CADAFUBP00005838; -.
DR   EnsemblFungi; EAL91406; EAL91406; AFUA_5G12070.
DR   GeneID; 3511615; -.
DR   KEGG; afm:AFUA_5G12070; -.
DR   VEuPathDB; FungiDB:Afu5g12070; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_014603_1_0_1; -.
DR   InParanoid; Q4WVH0; -.
DR   OMA; RKRWQSE; -.
DR   OrthoDB; 1175008at2759; -.
DR   Proteomes; UP000002530; Chromosome 5.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..513
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308749"
FT   DOMAIN          412..502
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   REGION          1..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          301..360
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..156
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..183
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..342
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  56750 MW;  32E0CDD75F6B7EA2 CRC64;
     MDDKSRGTTN AKHLATDTDH PPDDGSAGLP EPGSVKSKTG LFTARSTQKA LDGERDEFAT
     FRTRPPQQAA IAMQKPPVPV NKPVTLGRPN STPELRQTES QGSDDRAEPG YPMSKPVRNM
     TAGADTVENL LQDNRELPVR NPPIPHRNPA MHPDTSPRPP DIASVSGTKP RPTPPPPRKG
     GAKPVPKSPS RNEPKIHGEK QSYIPLSNSD VDLTGADEAR PTLPPRPDPS RVTHIPPSDH
     RILLEAHEHS KRHLTPSSPL LDRSLQNNGS SPDLIDYSPG LDEEAMSDAI VASSLASRKA
     FSAKKVPPPP PPQRQLRTHP LLRPNTPSSD SPRSSSPAPS LRHTLRPATK VGEEELDHHK
     HRKHIIRRHP HKHHEGDRKR WQSEVTEKER KRYEGVWAAN KGLLIPISNS KERSSLEEVS
     CEGYPPSASE MVLNIAVREI WARSRLPSSI LEKIWNLVDR QKIGLLTREE FVVGMWLIDQ
     QLKGHKLPVE VPGSVWDSVR GVPGIRIPKV PSR