ID   APRN_ENTHI              Reviewed;         640 AA.
AC   P20301;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 38.
DE   RecName: Full=Antigenic protein NP1;
DE   AltName: Full=Non-pathogenic protein 1;
DE   Flags: Fragment;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SAW 1734;
RX   PubMed=2544890; DOI=10.1073/pnas.86.13.5118;
RA   Tannich E., Horstmann R.D., Knobloch J., Arnold H.H.;
RT   "Genomic DNA differences between pathogenic and nonpathogenic Entamoeba
RT   histolytica.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5118-5122(1989).
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DR   PIR; B32935; B32935.
DR   AlphaFoldDB; P20301; -.
DR   VEuPathDB; AmoebaDB:EHI5A_021930; -.
DR   VEuPathDB; AmoebaDB:EHI7A_061750; -.
DR   VEuPathDB; AmoebaDB:EHI8A_065260; -.
DR   VEuPathDB; AmoebaDB:EHI_015380; -.
DR   VEuPathDB; AmoebaDB:KM1_119400; -.
DR   InterPro; IPR037524; PA14/GLEYA.
DR   InterPro; IPR031161; Peptidase_M60_dom.
DR   Pfam; PF13402; Peptidase_M60; 1.
DR   SMART; SM01276; M60-like; 1.
DR   PROSITE; PS51820; PA14; 1.
DR   PROSITE; PS51723; PEPTIDASE_M60; 1.
PE   4: Predicted;
FT   CHAIN           <1..640
FT                   /note="Antigenic protein NP1"
FT                   /id="PRO_0000064642"
FT   DOMAIN          <1..288
FT                   /note="Peptidase M60"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01060"
FT   DOMAIN          463..615
FT                   /note="PA14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01164"
FT   NON_TER         1
SQ   SEQUENCE   640 AA;  72353 MW;  15BEBD4A0C06F7BC CRC64;
     VQVSIGKCNH NPSDQWLDNI SRWSNDRMPI DSIGIDLGLQ TTQPYSINDT FKIGSPIGGM
     IYLRFDTTFT NSFYVTFYNV GRASIINYNI TMNEEWNSVL KNAPGNVAEI RTPGNRLVFT
     SRHIRNLEDA QYISDYWLKA ISISNYAVTL ENIPITLNFD QRVDAGAAVA FVDRWFTQHP
     SDWASGCVNK EGLINSGNWG PLHEMNHHMQ GPYLRGGNWG IKEPGEETNN VMTSINYILY
     TNIAGHRNQG LSGWNYVSDG YSTIYKILNG ENDQPHLRSY VNIAHAFGTD TLIALVKSYY
     GLWYENNYEG EYSIKRDSTS AFCLLAAIAT KRDTRYLCSL FKYDIQQNVS EAIKNMNYPT
     YYPFFNVYAM SYNGNYYGRT YKIPYGTTRL NFTATTAIDP SATSVSYTIK SGLTKGKLEQ
     VEENVYDYTP NFGADENDTF VLNIDCIVNG EKVHIEQDGT FELDPHQVEY EVYKDVKTKD
     MEQALNTIQN KTSNYTGTST FFDIGNYDDG TMQSMLVEKG KLIVPTSGYY TLFMKADDLG
     RLLLNVNGEY EQLLNVKTYL GGYSKTINGT YATVKLEKDT EYPFILYNLN TGGQGFIRIG
     YCYQGTDQSS VNVSKCSVLD IGSSMILNEK VKAGAKEPEF