ID   IRS4_BOTFB              Reviewed;         885 AA.
AC   A6S9V4;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=irs4; ORFNames=BC1G_09584;
OS   Botryotinia fuckeliana (strain B05.10) (Noble rot fungus) (Botrytis
OS   cinerea).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC   Helotiales; Sclerotiniaceae; Botrytis.
OX   NCBI_TaxID=332648;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B05.10;
RX   PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA   Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA   Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA   Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA   Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA   Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA   Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA   Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA   Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA   Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA   Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA   Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA   Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA   Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT   "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT   sclerotiorum and Botrytis cinerea.";
RL   PLoS Genet. 7:E1002230-E1002230(2011).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; CH476902; EDN30239.1; -; Genomic_DNA.
DR   RefSeq; XP_001551972.1; XM_001551922.1.
DR   AlphaFoldDB; A6S9V4; -.
DR   PRIDE; A6S9V4; -.
DR   GeneID; 5432488; -.
DR   KEGG; bfu:BCIN_08g02590; -.
DR   VEuPathDB; FungiDB:Bcin08g02590; -.
DR   OMA; KKHAHNE; -.
DR   OrthoDB; 1109591at2759; -.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism.
FT   CHAIN           1..885
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308751"
FT   DOMAIN          773..879
FT                   /note="EH"
FT   REGION          1..98
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          154..246
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          262..652
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          671..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          723..762
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        7..98
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        289..319
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        372..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        456..482
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        498..523
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..606
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        724..744
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   885 AA;  94374 MW;  94F7D20BBCB26D9E CRC64;
     MADAHSDGRT GSTTPGKITR PETTGTKNTH SDNASTSAPG NSASASASAS ASASTSTLHS
     NSSTTTSSPQ RMINHNPSTS SLRNINTGGT RIETGTGRGT GAVQNAALTG AALAFSNAMG
     KATPVVPNKF AGKTQLGGNG LGGKDGALAA ATKVRVGGGG SPNNGGGRTR SPSKVSVTDP
     GMGGEQQIYG YQKVGRERTG ESETDGGSVI SGGLEYQGGQ RIPQKRNQRP NGHLLPPFSG
     TSETSPNVKN NSAAFMAANL AAKRSRENSP SHTGQNYGMG MGMGKQASPL PSRRQSYASS
     IDSTDRRVDL SSIPPTSNLV EMWEQPDKGV KKERGLVSNR GNEIVNRQVQ KRPVSSHAPI
     PVLKPAGLTR PVSSHASESS VQSRIASSQA PISEQVKSKP KPVIHPRPSS SQASVPGPSK
     PVSKPDVQPP PVSSHTTSSE APKPSPKPPV QKPAIYNTRP ASSHGPVPNL STKPSIQKLS
     RPVSSHGPPP AKPSAKPSLQ SIRPTSSHTL ESTESSSKAS VQKPSLPPPR RTPANLSVSG
     DQSTSLPMHA PQPRSMQSPI LTTADRTEPA SESPTQSPRS SSTTKTPRRS SKPTLPSRPP
     VSRQSYNNDA DDDESSDDSF VSASSQPKPK SPSFRAKIAE QKRLQTSTYA PSMTAKTLSN
     AMVAGYLASS RASTPSISPG VIQPPAPPPP RRLKKFFHSE HSRTPTPPQN TLSATGVPTM
     KTTMRKPKTE KELKEEEGEG EKRRAKKHLV KKHPNKHDEG NRKRWRDEIT EKERKRYEAL
     WASNKGLFPY TMDPRGEIIE IEGAADTVPG MVVKDLWERS RLGGDVLEEV WELVHGKGYW
     GRQKQKRFGR LERDEFVVGL WLIDQRLKGR KLPARVNHSL WASAS