IRS4_CANAL
ID IRS4_CANAL Reviewed; 638 AA.
AC Q59SR6; A0A1D8PJU4;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Increased rDNA silencing protein 4;
GN Name=IRS4; OrderedLocusNames=CAALFM_C303660WA;
GN ORFNames=CaO19.14215, CaO19.6953;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC turnover and negatively regulates signaling through the cell integrity
CC pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR EMBL; CP017625; AOW28394.1; -; Genomic_DNA.
DR RefSeq; XP_712754.2; XM_707661.2.
DR AlphaFoldDB; Q59SR6; -.
DR SMR; Q59SR6; -.
DR BioGRID; 1228743; 2.
DR STRING; 237561.Q59SR6; -.
DR PRIDE; Q59SR6; -.
DR GeneID; 3645650; -.
DR KEGG; cal:CAALFM_C303660WA; -.
DR CGD; CAL0000177117; IRS4.
DR VEuPathDB; FungiDB:C3_03660W_A; -.
DR eggNOG; KOG0998; Eukaryota.
DR HOGENOM; CLU_020874_0_0_1; -.
DR InParanoid; Q59SR6; -.
DR OMA; PEFLVGM; -.
DR OrthoDB; 1070563at2759; -.
DR PHI-base; PHI:488; -.
DR PRO; PR:Q59SR6; -.
DR Proteomes; UP000000559; Chromosome 3.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0044406; P:adhesion of symbiont to host; IMP:CGD.
DR GO; GO:0009267; P:cellular response to starvation; IMP:CGD.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0036180; P:filamentous growth of a population of unicellular organisms in response to biotic stimulus; IMP:CGD.
DR GO; GO:0036170; P:filamentous growth of a population of unicellular organisms in response to starvation; IMP:CGD.
DR GO; GO:0031505; P:fungal-type cell wall organization; IMP:CGD.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR Pfam; PF12763; EF-hand_4; 1.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 1.
PE 3: Inferred from homology;
KW Lipid metabolism; Reference proteome.
FT CHAIN 1..638
FT /note="Increased rDNA silencing protein 4"
FT /id="PRO_0000308752"
FT DOMAIN 539..628
FT /note="EH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT DOMAIN 572..607
FT /note="EF-hand"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT REGION 15..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 270..356
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..440
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 29..64
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..354
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 410..440
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 638 AA; 71771 MW; C772E05653727C55 CRC64;
MSGNSAANAA ALAAFNGIGK KKKESTTKLN GTDNNTNHLG VIGSTSNQTK QHQQQQQQPQ
ALRTPLPAHP SRKKSNKFSQ LKRLNTAPAM ASLQPALQIA SPSISPTQPS APASALDSDP
DYFTLSPHTI PSKNEIAKSP QTPQDMIRNV RQSIELKAIP NNAQAKRLSV DYSPQEMLKN
LRHSLHSRTK TSPMLTTSDK MGQTMLAEMR DRLENTRRIA SNSVASLSLS PNLDFNKSTS
DVSNLSHHYD VDTVSTDSFA SFNSSINDRH LPHGISIDVT NHDSDEDEID DREREEDHEP
LDNGELKSTN NKVTVSSRLR RKPPPGEDFQ MQLNDKSRDT ISSGSYSLNP DEVYSFTDPD
SYENLVSEVE VGETTRLFPQ FPDANHYHQH SSKFRKKHQK VKPINGIYYR DMDSSNTSDT
EESTSNLPSR STTPLLGQPQ QQVHFRSTMR KANTKKDKKS RFNELKPWKN HNDLNYLTDQ
EKKRYEGIWA SNKGNYMSQV VIKLHGVNYE TQKDPKEEAK MEHSRTAALL SAAAVEDSNY
NGNNSLHNLD SVEINQLICG PVVKRIWKRS RLPSDTLEKI WNLIDFRRDG TLNKNEFLVG
MWLVDQCLYG RKLPKKVDNV VWDSLGGIGV NVTVKKKK
