IRS4_CANGA
ID IRS4_CANGA Reviewed; 870 AA.
AC Q6FJW0;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Increased rDNA silencing protein 4;
GN Name=IRS4; OrderedLocusNames=CAGL0M03157g;
OS Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS Y-65) (Yeast) (Torulopsis glabrata).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC Nakaseomyces/Candida clade.
OX NCBI_TaxID=284593;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC turnover and negatively regulates signaling through the cell integrity
CC pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR EMBL; CR380959; CAG62460.1; -; Genomic_DNA.
DR RefSeq; XP_449484.1; XM_449484.1.
DR AlphaFoldDB; Q6FJW0; -.
DR SMR; Q6FJW0; -.
DR STRING; 5478.XP_449484.1; -.
DR EnsemblFungi; CAG62460; CAG62460; CAGL0M03157g.
DR GeneID; 2891492; -.
DR KEGG; cgr:CAGL0M03157g; -.
DR CGD; CAL0136569; CAGL0M03157g.
DR VEuPathDB; FungiDB:CAGL0M03157g; -.
DR eggNOG; KOG0998; Eukaryota.
DR HOGENOM; CLU_329816_0_0_1; -.
DR InParanoid; Q6FJW0; -.
DR Proteomes; UP000002428; Chromosome M.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000261; EH_dom.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50031; EH; 1.
PE 3: Inferred from homology;
KW Lipid metabolism; Reference proteome.
FT CHAIN 1..870
FT /note="Increased rDNA silencing protein 4"
FT /id="PRO_0000308753"
FT DOMAIN 739..828
FT /note="EH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 38..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..579
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 717..738
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 150..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..209
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 210..225
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..547
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..563
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 564..579
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..735
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 96331 MW; AD0EB2060286ED33 CRC64;
MHMRLNKRRR NHVQEQMSEL PQDAKNDSLA AAQVIFKRHA DNANSTPPSP VGLDSAGHLD
KQADTAQRVH KVGTPSGTSS SHNSGNEGMH KVTKPLGENT ATTAPIAIKQ PVRVVRASPT
AIVSPTSHTP LDAATAAANV VAEKSKIRTT QQQLQDKKRR DIENAHHAAS AAAVTSSNLA
VGSPPSQYIP SVPTLNVTSP QMRNSSQNID RRSKSNEEAH NGHEKMMNSR SNSINSSTIK
GSVSEPNTVT PLRQNSPSNM DDIIQKMEAV DIDEGRKNSF VMNGSGDSVD SLKPNVVRRP
MRTPSGRRVR PPSPIDKIGS IQEPHLESTG FNDQNDFSEM SSLIDGSSSE DITKIRGSGI
RERSPVDGVE HGGMSVNIPM QRSLSSDVLS PSQQAAMVAA TKLSPSTQTL PVEELEYLAS
TGDVSAYKAL NKINGTNMAY KGTIPDLIPS RARAQKTSKL KFKIFGGGKN SDRRNNATPI
GYDPVMNIST DFGGKKVVES NQNNVKFKTT MRSQKYLGND NLDDNDLRTQ YIDDDDDDDD
YDSAYEDLDY SRDDSEAMYK GDRESSNPRS NSLLQSSSYS GKVGFNSNAN SGTSINNSGN
VSNLDYSLRD GVAEKKKSRR DKIKKKLKST ASVVPYYPHY ALTHLASGVS TVNSNLNNSN
KNTKWFNEDK PWKSHKDVGF VTSQERKRYE AMWVTNRYLY LNLLPWWPKE EVEKDEDDSA
SNLNSNASTN VGGVLSDGDN EEDDVTRFLL SLPADGLMLN LVAKDIWERS NLPNDLLKQI
YDLVDTRKDG TLNRESFLVG MWLVDQCLYG RKLPQELDPK IWDSVDRWVL NVVNSTMMTA
LERKQKKKMM KKELKNIKRE QKQAIAEQHN
