ID   IRS4_CHAGB              Reviewed;         741 AA.
AC   Q2H9M1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; ORFNames=CHGG_03083;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; CH408030; EAQ91148.1; -; Genomic_DNA.
DR   RefSeq; XP_001229599.1; XM_001229598.1.
DR   AlphaFoldDB; Q2H9M1; -.
DR   SMR; Q2H9M1; -.
DR   STRING; 38033.XP_001229599.1; -.
DR   EnsemblFungi; EAQ91148; EAQ91148; CHGG_03083.
DR   GeneID; 4389348; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_014603_0_0_1; -.
DR   InParanoid; Q2H9M1; -.
DR   OMA; KKHAHNE; -.
DR   OrthoDB; 1124641at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..741
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308754"
FT   DOMAIN          629..718
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   REGION          18..151
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          183..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          603..641
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        185..234
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        266..288
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        301..315
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        378..401
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        422..467
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        468..482
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        488..528
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        541..562
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..635
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   741 AA;  77173 MW;  D86C8DF1DEA936EF CRC64;
     MGAGLAPRGA NGALLAATQA ARGHAAAGGG NKGVNEGGSA AAAVGAGTGS GSGLDGGHGH
     GGGLVGQRVL DLHAGSGSGG GGSTLLPPPA GRSGADGGGG GGGRKSSPSL IAATLAASRS
     VSPARGPIPQ LDLNGGGGKV TRKRGQSVGA ASVIVGSVGP RHEAEVLDTA SIPPTTSLVS
     LFEGKREAND VDPVKKRAPS VRRKDMDTEE QARKERASQE PQKVKPKPVP KPKPKPEVAT
     DVAVPKSSDD AHGASEGTSR LGGTGRSGHG DERGRAEAKP SQRRARSQHS EHKPAKKPKP
     AQHRPPTPPP SLPTRSPSNH VVSQPKRVAK TPRLEPPTPP VKTSTIAKMA EPIVQVTPVE
     PDIDQVDVFH HQDRNPKPRQ VSQGSTSSND SFVSASSVPS GAVSPVREVE STPRRPAPPA
     RSPSSRSIST PNPPRQQASH PSTPNLTLSS LTNAMMASNL ASARLTPTTP SQPPPLPAPR
     RSGRSPLQPH HTADSIGSQL TGGSKSPNHA AHQQKQRTGM LQTLRSPHAS LSDDEDARRQ
     HHHRRRSKVL SGGNRKHAHH EGSRRRWRDE ITARERKRYE AVWASNRGLF LRPGWAAQYQ
     NTTTATTGGA SPTQQGHGPG TGEETQHQTR DQAVEASRAS HGAEAELVVN VVARDIWSRS
     RLPADELAEV WDLVDRGARG ALGRDEFVVG LWLIDQRLRG RKIPARVSQS VWDSAAGGYQ
     GVVVPLPGGG AGGGGRKGRR A