ID   IRS4_COCIM              Reviewed;         435 AA.
AC   Q1DKE6; A0A0D8JYL3; J3K2K1;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; ORFNames=CIMG_12312;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; GG704915; KJF61348.1; -; Genomic_DNA.
DR   RefSeq; XP_012213759.1; XM_012358336.1.
DR   AlphaFoldDB; Q1DKE6; -.
DR   SMR; Q1DKE6; -.
DR   STRING; 246410.Q1DKE6; -.
DR   EnsemblFungi; KJF61348; KJF61348; CIMG_12312.
DR   GeneID; 24164082; -.
DR   KEGG; cim:CIMG_12312; -.
DR   VEuPathDB; FungiDB:CIMG_12312; -.
DR   InParanoid; Q1DKE6; -.
DR   OMA; PGRINND; -.
DR   OrthoDB; 685488at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..435
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308755"
FT   DOMAIN          327..435
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   REGION          1..20
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          39..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          136..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..200
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..252
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        253..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   435 AA;  47532 MW;  5FBBEA34F418D7B6 CRC64;
     MKIPVTADAE SASKDGLQHD DIRATATVRD RIKQFSAEAS IPLEKASFSR QAPSQNPSIT
     AKPPIPPQRA ALKPGTKLVK ATGTELCGNQ QHGRSRNISP IAHFPAVPLS NKNTSAILSS
     DSETGAELAD RREFTASKAV RHGSRDPHAE MSSWKSPTPL PQRKKEAPPV PPRSSQLSTE
     SELLQLDPPS LHTDQEGSGV NHTLEVRESD ISDSALADAM TASYLIPSHA ALGSKRGLKQ
     PPPPPPPRQR GSPSQPLLQL SSDSSKVNPP ALGPDEILKR GMDMLDEPKS GSELPPKPPR
     RVTFNPNPEV FQIESGNVVQ GQVISSERKR YEEVWEANRG VARFGVMHDP NVDQKVIRKS
     LAYEDLVVDL VVRDIWSRSR LPQAELAKIW KLVSHDAVGM LSREEFVVGM WLIDQCLKGH
     GLPTNVPKSV WKSVQ