ID   IRS4_DEBHA              Reviewed;         765 AA.
AC   Q6BRH9;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; OrderedLocusNames=DEHA2D16236g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; CR382136; CAG87362.2; -; Genomic_DNA.
DR   RefSeq; XP_459191.2; XM_459191.1.
DR   AlphaFoldDB; Q6BRH9; -.
DR   SMR; Q6BRH9; -.
DR   STRING; 4959.XP_459191.2; -.
DR   EnsemblFungi; CAG87362; CAG87362; DEHA2D16236g.
DR   GeneID; 2901811; -.
DR   KEGG; dha:DEHA2D16236g; -.
DR   VEuPathDB; FungiDB:DEHA2D16236g; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_020874_0_0_1; -.
DR   InParanoid; Q6BRH9; -.
DR   OMA; PEFLVGM; -.
DR   OrthoDB; 1070563at2759; -.
DR   Proteomes; UP000000599; Chromosome D.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR000261; EH_dom.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..765
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308756"
FT   DOMAIN          663..753
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   DOMAIN          697..732
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          20..124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          187..206
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          321..362
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          390..466
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        21..72
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        81..124
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        394..412
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..442
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        443..466
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   765 AA;  86251 MW;  AA73514BB7BE9A5C CRC64;
     MASNNSTSQL AALAAFKAIN NKKNEESQPN NRSRIPLKVD TTAPPQTQMK ALNSATRAKS
     SNKISQTQAD KTRGQTSERK DQKTTPTGSN MTNIFKMPNT PKTPKISKSA ETPNSVGASR
     RSSTYSNSFA VESLENEPPK NDNFGEPLST VNNLERRKTV SQHSLNYDPQ DMIRNVKNSI
     GSKYISNDLS PGQVNTKRLS TGTQPKDMLD SVRNSINSKT KTNSKNQEMS QRNALILNGI
     RDSIDSKRIS SHHDNSTISL PLAEERDKIL KSISKSNNPE EQLMLYGQPI YNYSSSSFAS
     SFSENDNDQL RTPVIIRTDM DLLDPDSNAS IQHDERENYS NEDDDFEYND TYDTKEDKEV
     SPINIPLSSH ACARLGISNN DTPKTFMNLR IQTPDKEDSS RLKPKRKPPP EMDNDSISPT
     FTEQSDGYQT EGDDRMSDAS SNRTRRHSVQ YNDYGGYSDA SSKSQIKVND DSDYSYFDES
     DLSGSETPSV EKIDNDKSFL DDRLPIFPDI KAKSRKLFRN RKSKPIYNSD DPDTSKSDLQ
     SATEELKNIS VPSRTSTPVM GHQSQPVQLK ATMRTNKKRE KKYSFNENKP WKNHSELSYI
     AESERKRYEG LWVSNKGLYI NCAVSRFIGV DYNGKPEIES QIENQDAPTT AALLSSRTTN
     EDNSNVVQQN FHNLLSAETS QLIHGVVVKR IWKRSRLPKE TLEAIWDLVD FRKDGTLNKP
     EFLVGMWLVD QCLYGRKLPK KVDGTVWNSL GNVGLNVVLK KKGRR