IRS4_EMENI
ID IRS4_EMENI Reviewed; 552 AA.
AC Q5BH85; C8VQN2;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Increased rDNA silencing protein 4;
GN Name=irs4; ORFNames=AN0095;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC turnover and negatively regulates signaling through the cell integrity
CC pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR EMBL; AACD01000003; EAA65273.1; -; Genomic_DNA.
DR EMBL; BN001308; CBF90210.1; -; Genomic_DNA.
DR RefSeq; XP_657699.1; XM_652607.1.
DR AlphaFoldDB; Q5BH85; -.
DR SMR; Q5BH85; -.
DR STRING; 162425.CADANIAP00002655; -.
DR PRIDE; Q5BH85; -.
DR EnsemblFungi; CBF90210; CBF90210; ANIA_00095.
DR EnsemblFungi; EAA65273; EAA65273; AN0095.2.
DR GeneID; 2875869; -.
DR KEGG; ani:AN0095.2; -.
DR VEuPathDB; FungiDB:AN0095; -.
DR eggNOG; KOG0998; Eukaryota.
DR HOGENOM; CLU_014603_1_0_1; -.
DR InParanoid; Q5BH85; -.
DR OMA; RKRWQSE; -.
DR OrthoDB; 1158689at2759; -.
DR Proteomes; UP000000560; Chromosome VIII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000261; EH_dom.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50031; EH; 1.
PE 3: Inferred from homology;
KW Lipid metabolism; Reference proteome.
FT CHAIN 1..552
FT /note="Increased rDNA silencing protein 4"
FT /id="PRO_0000308757"
FT DOMAIN 451..540
FT /note="EH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 41..419
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 81..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 200..218
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..246
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 275..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..362
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 399..413
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 552 AA; 60419 MW; 639C0FD065788BAA CRC64;
MAKPSTPSRR VVLPRSLNNS TVNPPASAAA LQGALLAFSH AVPPKPQSPM MADRPPVSLL
DSDPDPPSEL PEPGSIKGKI ALFSANSTAT APSDRPRSAH ESVPEIARQK SPQLLAAEIA
TGSVQGPGGK TTSDDVQRTR LQRNGAVPSR DLSSPIPVRK PVINPRLLDP YQDETPEHSP
PKPGSDQRPV SSKSSASPRP PIRKPRPVPP PIPRKPSPAL SEPASKSASH RFENGLRRDE
ARKPPLPLRS KASAATLSEE RPPTLPPRRA ATAHDLYINQ STPGRAESPA GLSSSPSVVS
LYSPAHNASR TSVHTVASRD APSDAVAASS TASNRALQAR KSPPPPPPQR RRRSRSRSLL
HVQHKKDRTP NPSPGGLRET LRPQARSDDE DEQRRRQHKS HIINKHPHKH NEGERRRWRS
EITEKERKRY EGVWAANKGL LIHPSQVLDE NLEPDKIPPG MYPPAALDMV VNLVVRDIWS
RSRLPNHVLE QIWNLVDGQK IGLLTRAEFV VGMWLIDQQL RGHKLPAVVS ESVWASVTRV
PGISLEPYNT KH
