ID   IRS4_KLULA              Reviewed;         638 AA.
AC   Q6CSC2;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; OrderedLocusNames=KLLA0D02222g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00263.1; -; Genomic_DNA.
DR   RefSeq; XP_453167.1; XM_453167.1.
DR   AlphaFoldDB; Q6CSC2; -.
DR   SMR; Q6CSC2; -.
DR   STRING; 28985.XP_453167.1; -.
DR   EnsemblFungi; CAH00263; CAH00263; KLLA0_D02222g.
DR   GeneID; 2893346; -.
DR   KEGG; kla:KLLA0_D02222g; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_416228_0_0_1; -.
DR   InParanoid; Q6CSC2; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..638
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308758"
FT   DOMAIN          508..604
FT                   /note="EH"
FT   REGION          292..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          487..529
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   638 AA;  70365 MW;  F0C652CEF03F9231 CRC64;
     MRFRSRHQVD KPNVIVTQSN RKNEDRLGED ASLKAAQAMF KKHTVSQGFA VSDAPGTKLS
     LPNSGHGTPA HNVQAMARSS SSSSATSTPI NIIRRSPRSS LKGKPMGGLS VSPRTVEGNA
     ALSQQAAAVA LENEISGDES IVLVPAGNSN GSMTRSNSSI NAIRIVPGGG LSSSRSSSKV
     SIVKNSPTHS LALADKLNSI TLESVYGKPS TATGTATRTL AGRKAPPAAF IDQDSVLSND
     KHSENEDTPI KGTISYDTTA RMNVPVTYEG TLPDLIPGHQ RHKKKKWRNI FGSSATHGSS
     AGGAIGINGT SASGNDQYEN PSGTLSELQL NRAEDNLIVK SVNPTQKTRL QTTLRSNDYD
     RNSELAAVAG GYSSDESAFS SDSDRELHYA TDNHHNNSIN NHSSGVYYGN VGGNGVYNGG
     TAGVGRTKHR AMVRSHKRKS FNEDKPWKSH VDIGYISERE RKRYEGIWVT NRNSYLELLP
     WWNQPLQDEE QEQEQEREMD HESQHGLEEE LEEEREQESG QGQEQDADIP EDGLMLNLIV
     MEIWSRSNLS NQLLGQIYDK VDTRHDGTLN RQSFLTGMWL VDQCLYGRKL PKQIDQRVWD
     SVDKFVISIP NNNPHHRHRR RKKMLRKELK TIKKDLKT