ID   APRP_ENTHI              Reviewed;         639 AA.
AC   P20302;
DT   01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1991, sequence version 1.
DT   25-MAY-2022, entry version 44.
DE   RecName: Full=Antigenic protein P1;
DE   AltName: Full=Pathogenic protein 1;
DE   Flags: Fragment;
OS   Entamoeba histolytica.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=5759;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=ATCC 30459 / HM-1:IMSS;
RX   PubMed=2544890; DOI=10.1073/pnas.86.13.5118;
RA   Tannich E., Horstmann R.D., Knobloch J., Arnold H.H.;
RT   "Genomic DNA differences between pathogenic and nonpathogenic Entamoeba
RT   histolytica.";
RL   Proc. Natl. Acad. Sci. U.S.A. 86:5118-5122(1989).
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DR   PIR; A32935; A32935.
DR   AlphaFoldDB; P20302; -.
DR   VEuPathDB; AmoebaDB:EHI5A_021930; -.
DR   VEuPathDB; AmoebaDB:EHI7A_061750; -.
DR   VEuPathDB; AmoebaDB:EHI8A_065260; -.
DR   VEuPathDB; AmoebaDB:EHI_015380; -.
DR   VEuPathDB; AmoebaDB:KM1_119400; -.
DR   eggNOG; ENOG502RF7K; Eukaryota.
DR   InterPro; IPR037524; PA14/GLEYA.
DR   InterPro; IPR031161; Peptidase_M60_dom.
DR   Pfam; PF13402; Peptidase_M60; 1.
DR   SMART; SM01276; M60-like; 1.
DR   PROSITE; PS51820; PA14; 1.
DR   PROSITE; PS51723; PEPTIDASE_M60; 1.
PE   4: Predicted;
FT   CHAIN           <1..639
FT                   /note="Antigenic protein P1"
FT                   /id="PRO_0000064643"
FT   DOMAIN          <1..287
FT                   /note="Peptidase M60"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01060"
FT   DOMAIN          462..614
FT                   /note="PA14"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01164"
FT   NON_TER         1
SQ   SEQUENCE   639 AA;  72087 MW;  4752187AB956AEB5 CRC64;
     IQVGIGKCNH NPSDQWLNVN NWSNDRMPID SIGFDLGLNT TQPYIINDTF KIGSPFGGMI
     YLRSDTTFTN SFYVTFSNVG RAPIINYNIT TNEEWNSVLR NAPGNVAEIR TPGNRLVLTS
     RNIRSLEDAQ YISDFWLKAI SISNYAVTLE NIPITLNFDQ RVDAGAAVAY VDRWFTQNPS
     DWAAACVGKD GLINYGNWGP LHEMNHHMQG PYLKGGNWGI SNPGEETNNV MTSINYILYT
     NIAGHRNQGL SGWNYVSDGY STIYKILKGE NDQPHLRSYV NMAHAFGTDT LIALVKSYYG
     LWYENNFESK YSIKRDSTSA FCLLAALVTK RDTRYLCSLF KYDIQSNVSE AIKNMNYPTY
     YPFFNLYAMS YNGNYYGRPY KIPYGRTRLN FTATCSIDPK ATSVSYTIKS GLTKGKLERV
     EDNVYDYTPF FGIEENDTFV LNIDCVVNGE KVHIEQEGTF ELDPHQVEYE VYKDVQTRDM
     AQALNIIQNK TANDTGRASF FDIGTYNDGS MQSMLVEKGK LIVPKSGYYT LFMKADDLGR
     LLLNITGEYE QLLDVKTYLG GYSKTLNGSY ATVKLEKDVG YPFILYNLNT GGQGFIRIGY
     CYHGTEESSV DVSKCSVSDI GSSMVLNEKV KTGAKEPEF