ID   IRS4_LODEL              Reviewed;         882 AA.
AC   A5DZL0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; ORFNames=LELG_02797;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; CH981526; EDK44618.1; -; Genomic_DNA.
DR   RefSeq; XP_001526239.1; XM_001526189.1.
DR   AlphaFoldDB; A5DZL0; -.
DR   SMR; A5DZL0; -.
DR   STRING; 379508.A5DZL0; -.
DR   PRIDE; A5DZL0; -.
DR   EnsemblFungi; EDK44618; EDK44618; LELG_02797.
DR   GeneID; 5233038; -.
DR   KEGG; lel:LELG_02797; -.
DR   VEuPathDB; FungiDB:LELG_02797; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_020874_0_0_1; -.
DR   InParanoid; A5DZL0; -.
DR   OrthoDB; 1070563at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR000261; EH_dom.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..882
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308759"
FT   DOMAIN          783..872
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   DOMAIN          816..851
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          15..36
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          69..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          217..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          378..409
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          424..448
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          567..674
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          748..769
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        381..395
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..610
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        611..662
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   882 AA;  97780 MW;  8D0FD31ECA9A3068 CRC64;
     MASGTAANAA ALAAFNAGKK RDDGWKQNNE GNNKSSKYVC APAVKSQNNK VKPAAPAAPA
     ALAGAVNTNT TNTTNTVTTT SASTTPKPKS NHAVHRDTTP TSMVNQQYSQ NNDRIMTKSP
     RPVLNVNTDS SKQGSYSSAA SKNNHDNKGL DYFNLGSATS GRSDTFKLPR YLPHTPKDMI
     NNVKSSIEAK NIANDPSSRR LSANYSPQQM LKNLKTSLNE KSKAPAPPKA SENDKGRQIL
     SDMRERLDTS RKIAADQAAT RGLAPGFDFE EDGDKEDKGY EDYTWNLTDR KKPVSSNRSA
     KSFKSFKSVK STNSNKTVNS IAKNVVTKAG ENDQLGTTEL NISTPERHGI CIDVTYHDSD
     VEDDCLKNEN GNKCANGIGH ENGHGTQNEN NVENGIRNEN QHDNESDIGD QVMVPIKLYN
     SDKSSISSKS KVRRKPPPSL SQEEYGSSST ELLSTDLKHI MALHAKSSDT FSSGDNFNQS
     DDQISIAEND AGQPNVGTTA AATLVRRGDT KFPQFPEIKK KHYHSRNIFG LKRHDHRNQN
     SVIWLDPDSD VEAEGEGLGG EAKYVRGVNR KSAGEDDELE EEEEEEQDGE EEEEEEEEGN
     EVEENEESEF SDASAIANNF NHGNTKNGVR RLGPQSRPQQ AHVQQQQPQQ SQQQPVQFRT
     TMRTTNKRKD RKSKFDEYKP WKNHSDLNYL TDQERKRYEG VWVSNKGNYT NLVVVKLHGV
     DYSTVKDGKV NLEHIDDSMR AALISTNAYP SSKQEEQESM KSNNGTGIKV NSDGSVYNSA
     IEVPSQANNQ SRPERVELSQ LILGAVVKRI WSRSGLPDET LEQIWNLVDF RRDGTLTKNE
     FIVGMWLVDQ CLYGRKLPKK VESIVWESLG GIGVNINTKK MR