ID   IRS4_MAGO7              Reviewed;         680 AA.
AC   A4QST9; G4N5N5;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JAN-2012, sequence version 2.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; ORFNames=MGG_05273;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; CM001233; EHA53025.1; -; Genomic_DNA.
DR   RefSeq; XP_003712832.1; XM_003712784.1.
DR   AlphaFoldDB; A4QST9; -.
DR   SMR; A4QST9; -.
DR   STRING; 318829.MGG_05273T0; -.
DR   EnsemblFungi; MGG_05273T0; MGG_05273T0; MGG_05273.
DR   GeneID; 2675716; -.
DR   KEGG; mgr:MGG_05273; -.
DR   VEuPathDB; FungiDB:MGG_05273; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_014603_0_0_1; -.
DR   InParanoid; A4QST9; -.
DR   OMA; TVDHTYP; -.
DR   OrthoDB; 1124641at2759; -.
DR   Proteomes; UP000009058; Chromosome 3.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..680
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308760"
FT   DOMAIN          568..674
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   REGION          1..341
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          361..451
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        70..85
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..154
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..240
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        247..261
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        281..300
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..321
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        420..451
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        466..483
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        491..514
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        537..556
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   680 AA;  74009 MW;  96EAD3E382D35990 CRC64;
     MTIMTSPAHR PPASSLSIPH EQAQSAALKG ASLAFQKQLD ASKKKASPPG PNHNNKLTTD
     PRGGALVAAT SAASLSNQTT GGSSVADHHH GVPEHATLSS RLAQLQQRSG SPHLRPPGNA
     GGPRSASFIA ATLAASRSTS PSPSRKNSVV TPQEQRRRAG AHSRASSVGS LRLTSPSNLG
     PSPGQGVDYG GYDGEDDADL DHDEDTGFRR LGRRKVVAET PTLPAREQSR RRDGDPVKSP
     SPVRDTEVPQ PRRKVIDRVP EQEEPASPVQ KPRPKPKPKP KPKPEKIIKT EPRAAPEPVE
     SKRAEQYPGS EPTSPSIRRA SVQQPKPKVA RAQPARTPIK AYHSQKEIQV LSRILMPKDV
     DDIDCGPLTL DGAHGPPFRE RVDSISSDDT FFSTSSGQGR RAPTPPPPRR IRSVRETPSR
     PHSEATTPSS QQRSTSSQSK QTPTSANRSS LALDSLTNAI VASSLASARH TPASRSQTPA
     PVPVPSRKRN DRLASNLTGG GMSRSHSRSP PKKQGMLTTL RAPHSKSDDE EARKHKERHR
     KRGPLGGKKH VHHEGSRRRW RDSVTAEERR RYEALWASNR GLLLPPKDGG VGQQHQQQQP
     EDLVANVVVR DLWSRSRLPH DELAEVWDLV DLGRRGSLSK EEFVVGMWLI DMRLRGRKIP
     PRVSQSVWDS VKGLRVPAPA