ID   IRS4_NEOFI              Reviewed;         513 AA.
AC   A1DDY6;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=irs4; ORFNames=NFIA_075220;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; DS027696; EAW17593.1; -; Genomic_DNA.
DR   RefSeq; XP_001259490.1; XM_001259489.1.
DR   AlphaFoldDB; A1DDY6; -.
DR   SMR; A1DDY6; -.
DR   STRING; 36630.CADNFIAP00008210; -.
DR   EnsemblFungi; EAW17593; EAW17593; NFIA_075220.
DR   GeneID; 4586307; -.
DR   KEGG; nfi:NFIA_075220; -.
DR   VEuPathDB; FungiDB:NFIA_075220; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_014603_1_0_1; -.
DR   OMA; RKRWQSE; -.
DR   OrthoDB; 1175008at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..513
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308761"
FT   DOMAIN          412..502
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   REGION          1..383
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..21
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        169..183
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        194..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        240..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..274
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        318..343
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        361..376
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  56845 MW;  7038341E71ACA6C4 CRC64;
     MDDKSRGTTD AQHHATDADR PPDDGSAGLP EPGSVKSKIG LFTAQSTQKA LEGERDKSAT
     FRPRPPQQAA AQLAMQKPPV PVNKPVTLGR MNSTPELRQT EPQGSDDRAE PDLPMPKPVR
     NMTADADTVE KLLQDNRELP VRNPPILHRN PAMQPATSPR SPDIASVSAT KPRPPPPRKG
     GAKPVPKSPS RSEPKIHGGQ QSYEPLSNSD MDLTGADEAR PKLPRRPDAS PVTHIPPSDH
     RVLLEAHERS KRHLAPSSPL LDRSLQNNGS SPDLIDYSPG LDEEAMSDAI VASSLASRKA
     PSAKKFPPPP PPQRQRGTHS LLRPNTSNSD SPRSSSPASS LRHTLRPPTK IGEEEFDHHK
     HRKHIIHRHP HKHHEGDRKR WQSEVTEKER KRYEGVWAAN KGLLIPISNS KERSSHEETS
     SECYPPSASE MVLNIVVRDI WARSRLPSSI LEQIWNLVDR QKIGLLTREE FVVGMWLIDQ
     QLKGHKLPVK VPDSVWDSVR GVPGIRIPKV PSR