IRS4_NEUCR
ID IRS4_NEUCR Reviewed; 856 AA.
AC Q7SB65;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Increased rDNA silencing protein 4;
GN Name=irs-4; ORFNames=NCU06276;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC turnover and negatively regulates signaling through the cell integrity
CC pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR EMBL; CM002238; EAA33644.1; -; Genomic_DNA.
DR RefSeq; XP_962880.1; XM_957787.3.
DR AlphaFoldDB; Q7SB65; -.
DR SMR; Q7SB65; -.
DR STRING; 5141.EFNCRP00000006026; -.
DR EnsemblFungi; EAA33644; EAA33644; NCU06276.
DR GeneID; 3879019; -.
DR KEGG; ncr:NCU06276; -.
DR VEuPathDB; FungiDB:NCU06276; -.
DR HOGENOM; CLU_014603_0_0_1; -.
DR InParanoid; Q7SB65; -.
DR OMA; KKHAHNE; -.
DR Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000261; EH_dom.
DR Pfam; PF12763; EF-hand_4; 1.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50031; EH; 1.
PE 3: Inferred from homology;
KW Lipid metabolism; Reference proteome.
FT CHAIN 1..856
FT /note="Increased rDNA silencing protein 4"
FT /id="PRO_0000308762"
FT DOMAIN 743..832
FT /note="EH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT REGION 1..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 230..563
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 69..87
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..152
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..204
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 332..346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 514..544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..622
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 638..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 92215 MW; 244AF3943F196C1F CRC64;
MSASVTSSDG RGPASPTSSS TGASTNPATS GLAAALKGAT LAFQHQQRTA AKGSDTAVPR
PHGGSRVPTP GTGSVSTSTS RTVGGSNGAR LAATLAAREH SPPTTSKNEA SRVVTSTPSS
SSSVGSAGRT NRQELHGQAT GGSSQQQQQQ QHVEERANDH APSKRPAMRS RRPSLASLSS
QAVDNSHSHP PTPASAKPSS EPKSVSWIAA TLAATSIAPT TSLVAMFDGK QEEAETATKK
KKKKKPRPAS KTQHHQTLTS PSPTPSEGLS IENQCGTGGV PSVASGKSKV APKPKPKPRR
DISLSTVESI KSSTGAMGRD GKSSNQEQGE TRNRNGDVRD KPSREGGKVT VTGAKDIVFE
GTSERRSQQK VPATPRSVQS KQGVEVPTDK RPSTPPVSQH AQISETTIIS PQPRRVVSTP
RLESSPAVPK TYKTVTNPRP DNKPTIRKSS RVVSPSVDQS QTIRQSAETG LGDRHTSRNS
TSSDETFVSA SSSPSPRPQT PTKELERVRP RLDRANTSTS SRASRVSTPA SVRSPASQTR
PSPVLRPGTG LYSYSTGASP TPEMSLDSLT NAMIASNLAS SRLTALTQTS LESPGLPPVP
PPRRGHRHHH LPHPHLRHRT QSPPHARPLI PQRTADSLPV RTGPSRQTEH TQPASLLKTL
RAPRSLSDDE DLRLQTHRHR KKHLGGKKHA HNEGARRRWR DEMTIRQRRR YEAVWASNRG
LFLRPGFAFE HPENWQPLPP PDDSLGQVDL SRAWESPEAD LVVNVVVRDI WSRSRLPVDE
LAEVWELVDR RKCGALDKQE FVVGMWLIDQ RLRGRKIPTV VGEGVWESAM DRVLSVNVKA
PKAHKGRTKG HLKGVF
