ID   IRS4_PICGU              Reviewed;         667 AA.
AC   A5DBE7;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=Increased rDNA silencing protein 4;
GN   Name=IRS4; ORFNames=PGUG_00602;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK36504.2; -; Genomic_DNA.
DR   RefSeq; XP_001487225.1; XM_001487175.1.
DR   AlphaFoldDB; A5DBE7; -.
DR   SMR; A5DBE7; -.
DR   STRING; 4929.XP_001487225.1; -.
DR   PRIDE; A5DBE7; -.
DR   EnsemblFungi; EDK36504; EDK36504; PGUG_00602.
DR   GeneID; 5128806; -.
DR   KEGG; pgu:PGUG_00602; -.
DR   VEuPathDB; FungiDB:PGUG_00602; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_020874_0_0_1; -.
DR   InParanoid; A5DBE7; -.
DR   OMA; PEFLVGM; -.
DR   OrthoDB; 1070563at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR000261; EH_dom.
DR   Pfam; PF12763; EF-hand_4; 1.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..667
FT                   /note="Increased rDNA silencing protein 4"
FT                   /id="PRO_0000308763"
FT   DOMAIN          568..661
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   REGION          1..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          133..152
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          234..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          459..488
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        41..83
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..123
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        234..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        292..315
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        320..347
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..398
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        412..426
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   667 AA;  73894 MW;  377F20871A8DDA2F CRC64;
     MSAGQSTSQA AALAAFKSIS THPKTDQNPS KVHQSPERNV KRNPSGRLTN SRNATAVNAI
     NRSPPKAPQK PQLSVVTASG HETKKNVENN RQRSSSPSPL YRTTTPKQMT SPSTSSASLP
     SNMIKSVKDS IEAKRHASEA KRLAQENQPS DMLTKIRQSI NDRTRNIPNQ AKVNERNMAT
     INGIRESIES KRITTQANSS MIVLDTSSNS PYNFAPPDEL RSPYEAHSPN YSYSSFESVP
     SAYSNPDSNI DLHDRGPETP SIVVDSPFNS QYDLSSPRED SDIDQERRNT APILIPPSSN
     ACARSANSAG SADDARSHLS SLKYQVEKEK NEDKNKKPKR KPPPELKPTT DLDGAFFSDS
     SSLNPGSSRS SLDAGSYSTD NESMGRNRMG SNDSDLSKPI KLPQYPELDT SSTKFKIRKR
     HGESNQNVGK MTESGSESDF EYPKATVPVS RATAPPLVHQ KSQHVQLKTT MRDSKKKKKD
     KKSFDVDKPW KNHSDLDRIS EADRKRYEGV WASNRGTYFN YVVTRINGID YGSGGGSEQK
     IIVDEEDSMK AARLSAKQQA DTVSGANGGY QSAEFHNITN AEISQLIHSS VVERIWERSR
     LPSETLRDIW ELVDYRKDGT LNKPEFLVGM WLVDQCLYGR KLTKKVPASV WESLEGIGVS
     VKKKGKR