ID   IRS4_SCHPO              Reviewed;        1379 AA.
AC   O14066; Q9UQW4;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   11-JAN-2001, sequence version 2.
DT   25-MAY-2022, entry version 118.
DE   RecName: Full=Increased rDNA silencing protein 4 homolog;
GN   ORFNames=SPAC1687.09;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC       turnover and negatively regulates signaling through the cell integrity
CC       pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR   EMBL; CU329670; CAA22603.1; -; Genomic_DNA.
DR   PIR; T37752; T37752.
DR   RefSeq; NP_593127.1; NM_001018523.2.
DR   AlphaFoldDB; O14066; -.
DR   BioGRID; 279203; 13.
DR   STRING; 4896.SPAC1687.09.1; -.
DR   iPTMnet; O14066; -.
DR   MaxQB; O14066; -.
DR   PaxDb; O14066; -.
DR   PRIDE; O14066; -.
DR   EnsemblFungi; SPAC1687.09.1; SPAC1687.09.1:pep; SPAC1687.09.
DR   GeneID; 2542753; -.
DR   KEGG; spo:SPAC1687.09; -.
DR   PomBase; SPAC1687.09; -.
DR   VEuPathDB; FungiDB:SPAC1687.09; -.
DR   eggNOG; KOG0998; Eukaryota.
DR   HOGENOM; CLU_255729_0_0_1; -.
DR   InParanoid; O14066; -.
DR   PRO; PR:O14066; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0032153; C:cell division site; HDA:PomBase.
DR   GO; GO:0051286; C:cell tip; HDA:PomBase.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; HDA:PomBase.
DR   GO; GO:0044732; C:mitotic spindle pole body; HDA:PomBase.
DR   GO; GO:0005730; C:nucleolus; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000407; C:phagophore assembly site; ISO:PomBase.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISM:PomBase.
DR   GO; GO:0006914; P:autophagy; ISO:PomBase.
DR   GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR   GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd00052; EH; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR000261; EH_dom.
DR   SMART; SM00027; EH; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50031; EH; 1.
PE   3: Inferred from homology;
KW   Lipid metabolism; Reference proteome.
FT   CHAIN           1..1379
FT                   /note="Increased rDNA silencing protein 4 homolog"
FT                   /id="PRO_0000116738"
FT   DOMAIN          1240..1329
FT                   /note="EH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00077"
FT   DOMAIN          1273..1308
FT                   /note="EF-hand"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          138..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          337..370
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..573
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          768..816
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1047..1110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1168..1208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        139..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        260..296
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1379 AA;  150018 MW;  9720ADEA099C56E8 CRC64;
     MDAIHPVSLR NSKRHPLLHS ERNLSRRAVS PSISRSFFQH SNGSFPLFQN HRKSLPSAIY
     KSVDPYVDAN PLDPLAAAKA SFADFPEQDD SQSSTSPLSS KYHTKKNKQI FVEDSRRGGA
     ASNAAAIAAK KSGYYERTST RKRSLTVPTP RTSFPHHPRS RRFSLKNAAI ATSYHKFKPL
     SSNSLSSSGM HFSASKQAFN SPLLQTFSPS PSVSPFSNPA VEKLKTSASK QAAEAQSLRE
     FDFFTPTPEP SDKNLEKLKN GASKQASESQ SLKNMESLSL ARSSPILTSE KLKNGASKQA
     IESPPFRASE PLPSSNIIPN PAMERLKNGA SKLAIESQPF KSAEPLSSAI PLPNPMSEKM
     RNGASKQAIM AQSSKINPLP PLTASISDPS FEKLKNTASK QAIESQSLMN SGPELLEPSI
     SDPMLEKMKT DAGKQTVESL SLKSSDATIP KPSVSDLGVE KLKNDASKCA VESQSLMIND
     PSVSSTSFYN PNMEKLKNGA IKQAIEHQAL NAAILNKTQL PYFHQSSSEL PISASKRAAL
     SQQTESASKS SSNISEMCDS HPPSNFSISA SQQASKDRFS EATSSIDLDL SPGRSLSLAS
     SKLSVKEAGA RVYNRSVATP VMTPSNPFEI SKSASQLASI AQVPVSEPAK TSEVNLKKSL
     SLASSKLSFQ EAGTSLKEKT ANVQHSPEVL NDRSLASLSA SRHADAISSK SKQHTEIAQP
     AFNTTGTVLM KTKSNLSDSA LSTPQHSDSV LFDITSKAAR LASTCAKTDL HRKPRRKHKS
     FTLENYFGHN AEDESPQSDE VESQTPPSGY SENDIGGTDI YPFALQGAAL AAAKDFSRRE
     ASLSDSQSAA SMDMLPMKKK LSHSSASSTR SIKSLLTNAN QKHIHSSINE TDDIPTMAAH
     IVATGQKNKE KAPSFSNDQA LDHLLGSAHK RIPSNKTEWS SSSLHIPSHN SFSDIHHRKI
     AAHAAAITAA SEKLTPSIEE TSYSSSKAHD ASLSAATLVA NKDKLIHAPT PQVLAPVLPK
     VSLPHRHSVS LGQIRGESEV EGDVFYDAPS DKEDLGSSNA PLDVPHGANR SSMDEVNGSK
     YDYSDGILDG SGQYTDSDMS DDENSLKDSQ SSVLSFSAVP TKVLKFKLRD VLGSEYSPSP
     QLLASSSDVS GSSSAVRAAM KADKIFPAVH ENPPPLKTKQ SIAKPSPHTL RVPQKKHKHF
     YHRDDGKYKS GTNLRKSETV DLPQFFIDEN RRKLYEGLWA ANKGYLLSKS EYSKPNDLIC
     NIVVRELWSR SGAPTSVLAK IYDLVDRHHT GVLGRDEFIV GMFLIDQYLK GRKLPLKVPD
     SVWLSSKRMG DMLWRLEKLQ KKTDNKKPFF KKKKKKRKHL KKFFDFNTTA KVNEGAMTD