IRS4_SCLS1
ID IRS4_SCLS1 Reviewed; 923 AA.
AC A7EDF3;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 1.
DT 25-MAY-2022, entry version 64.
DE RecName: Full=Increased rDNA silencing protein 4;
GN Name=irs4; ORFNames=SS1G_03343;
OS Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1) (White mold)
OS (Whetzelinia sclerotiorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Sclerotinia.
OX NCBI_TaxID=665079;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 18683 / 1980 / Ss-1;
RX PubMed=21876677; DOI=10.1371/journal.pgen.1002230;
RA Amselem J., Cuomo C.A., van Kan J.A.L., Viaud M., Benito E.P., Couloux A.,
RA Coutinho P.M., de Vries R.P., Dyer P.S., Fillinger S., Fournier E.,
RA Gout L., Hahn M., Kohn L., Lapalu N., Plummer K.M., Pradier J.-M.,
RA Quevillon E., Sharon A., Simon A., ten Have A., Tudzynski B., Tudzynski P.,
RA Wincker P., Andrew M., Anthouard V., Beever R.E., Beffa R., Benoit I.,
RA Bouzid O., Brault B., Chen Z., Choquer M., Collemare J., Cotton P.,
RA Danchin E.G., Da Silva C., Gautier A., Giraud C., Giraud T., Gonzalez C.,
RA Grossetete S., Gueldener U., Henrissat B., Howlett B.J., Kodira C.,
RA Kretschmer M., Lappartient A., Leroch M., Levis C., Mauceli E.,
RA Neuveglise C., Oeser B., Pearson M., Poulain J., Poussereau N.,
RA Quesneville H., Rascle C., Schumacher J., Segurens B., Sexton A., Silva E.,
RA Sirven C., Soanes D.M., Talbot N.J., Templeton M., Yandava C., Yarden O.,
RA Zeng Q., Rollins J.A., Lebrun M.-H., Dickman M.;
RT "Genomic analysis of the necrotrophic fungal pathogens Sclerotinia
RT sclerotiorum and Botrytis cinerea.";
RL PLoS Genet. 7:E1002230-E1002230(2011).
CC -!- FUNCTION: Positive regulator of phosphatidylinositol 4,5-bisphosphate
CC turnover and negatively regulates signaling through the cell integrity
CC pathway. Involved in rDNA silencing (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR EMBL; CH476624; EDO00869.1; -; Genomic_DNA.
DR RefSeq; XP_001595254.1; XM_001595204.1.
DR AlphaFoldDB; A7EDF3; -.
DR STRING; 665079.A7EDF3; -.
DR EnsemblFungi; EDO00869; EDO00869; SS1G_03343.
DR GeneID; 5491743; -.
DR KEGG; ssl:SS1G_03343; -.
DR VEuPathDB; FungiDB:sscle_07g057320; -.
DR eggNOG; KOG0998; Eukaryota.
DR HOGENOM; CLU_327097_0_0_1; -.
DR InParanoid; A7EDF3; -.
DR OMA; KKHAHNE; -.
DR Proteomes; UP000001312; Unassembled WGS sequence.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IBA:GO_Central.
DR GO; GO:0016197; P:endosomal transport; IBA:GO_Central.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000261; EH_dom.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
PE 3: Inferred from homology;
KW Lipid metabolism; Reference proteome.
FT CHAIN 1..923
FT /note="Increased rDNA silencing protein 4"
FT /id="PRO_0000308765"
FT DOMAIN 800..906
FT /note="EH"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 247..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..232
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 276..290
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..345
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..398
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..511
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 522..551
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 561..575
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 600..625
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..678
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..786
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 923 AA; 97434 MW; B3FFB85246FF4C6A CRC64;
MADPIFNGDA SDTKTAKLTR PVTGTSTAAR NTQQSAAFEN SASVSASTST LQSTTSSTPR
INHNPSINSL RNTHVGGAGT ETGRGISAAQ NAALTGASLA FSNAKEGRAK ARVVPPVPNK
GNVQLGEKGL NGNGGALAAA AKAGAVGHNA GGGGRTRSPS KVSAMDEGTV HGQHILGSEK
TGESQTTDGG SINGRLEHQI GHTGLQKRKQ RSNGHLLPPF SGSGNSMTEH GANMKSSSAA
FMAANLAAKR SRESSPSQSH GTGIGIGGGL GKQGSPLMSR RQSYASSIDS LDRRLDVSSI
PPTSNLVGMW EQANRGVKKG GAGGGGESSS DRGNEVVSRQ ESLRRPASSH APVPVLKPEG
LTRPVSSHVP DVELVKSSAT KPAVQPPNTS SQASISDEIK SPGKPAVQPQ IVYSHTSELE
PKKSAAKASV PLRPSSSQDL ISEETKSTSK PAVQQRPVSS YTPGSVTLKP SSKSPAQKPV
IHNTRPVSSH GPSPNFSAKP SIQKLSRPVS SHSPPPTKPS AKPSSQSIRP ISPRAMESTE
SLSKSPVQKP SIPPSRHTPA DAPALNTQSA KPQVQAPRPL SMHSPILKPA DRDEPSLKPP
VQPPRHSSTK TPPKSPRPKP PFEPPVSKQS YNNNYDDDDG SSDDSFVSAS SQPKPKSPSF
RAKIAQQKRS QSTSISSMNV NSLANAIVAG SLASSRASTP SISSGTTRAP APPPTRRHKN
LHIFHSDNSR TPTPPHNNGS AAGVPIMKTT MRKPKTGKEL KEEEGEGEKR RAKKHLVKKH
PNKHNEGNRK RWRDGITERE RKRYEAVWAS NKGLFPYTIN QDGEMVEVDG AVDTVPGIVV
RDIWERSRLG EDVLEEVWGL VEGRGYRSRL VANMKAGGRL EKDEFVVGLW LIDQRLKGRK
LPGRVGSSVW GSAGPMGGIK IRS
